研究者
J-GLOBAL ID:201601012114917828   更新日: 2024年06月29日

石津 綾子

Nakamura-Ishizu Ayako | Nakamura-Ishizu Ayako
所属機関・部署:
職名: 教授
研究分野 (1件): 解剖学
研究キーワード (5件): quiescence ,  mitochondria ,  megakaryocyte ,  niche ,  hematopoietic stem cell
競争的資金等の研究課題 (6件):
  • 2022 - 2027 オルガネラ恒常性による造血幹細胞維持と血小板分化調整機構の解明
  • 2018 - 2021 細胞エネルギー代謝を介する造血幹細胞の巨核球分化機構の解明
  • 2014 - 2019 造血幹細胞のホメオスターシスの維持と破綻
  • 2014 - 2018 巨核球による造血幹細胞運命制御の解明
  • 2016 - 2018 巨核球による造血幹細胞運命制御の解明(国際共同研究強化)
全件表示
論文 (34件):
  • Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Takayuki Morikawa, Shinya Fujita, Kotaro Shide, et al. SDHAF1 confers metabolic resilience to aging hematopoietic stem cells by promoting mitochondrial ATP production. Cell stem cell. 2024
  • Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinpei Tamaki, Miho Haraguchi, Masamichi Yamamoto, Ayako Nakamura-Ishizu, Shinichiro Okamoto, et al. Distinct roles of the preparatory and payoff phases of glycolysis in hematopoietic stem cells. Experimental hematology. 2023
  • Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shuhei Koide, Motohiko Oshima, Akira Nishiyama, et al. Context-Dependent Modification of PFKFB3 in Hematopoietic Stem Cells Promotes Anaerobic Glycolysis and Ensures Stress Hematopoiesis. bioRxiv. 2023
  • Makiko Mochizuki-Kashio, Noriko Otsuki, Kota Fujiki, Sherif Abdelhamd, Peter Kurre, Markus Grompe, Atsushi Iwama, Kayoko Saito, Ayako Nakamura-Ishizu. Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells. Frontiers in Oncology. 2023. 13. 1108430-1108430
  • Kohei Shiroshita, Hiroshi Kobayashi, Shintaro Watanuki, Daiki Karigane, Yuriko Sorimachi, Shinya Fujita, Shinpei Tamaki, Miho Haraguchi, Naoki Itokawa, Kazumasa Aoyoama, et al. A culture platform to study quiescent hematopoietic stem cells following genome editing. Cell reports methods. 2022. 2. 12. 100354-100354
もっと見る
MISC (4件):
  • Ayako Nakamura-Ishizu, Takayoshi Matsumura, Terumasa Umemoto, A'Qilah Abdul Majeed, Toshio Suda. RAPID AND DIRECT MEGAKARYOCYTE-LINEAGE DIFFERENTIATION FROM HSCS HALLMARK HEMATOPOIETIC SYSTEM RESPONSE TO STRESS. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S91-S91
  • Ayako Nakamura-Ishizu, Toshio Suda. CLEC-2 SIGNALING IS CRUCIAL FOR THE PRODUCTION OF THROMBOPOIETIN IN THE MEGAKARYOCYTE NICHE. EXPERIMENTAL HEMATOLOGY. 2015. 43. 9. S45-S45
  • Ayako Nakamura-Ishizu, Hitoshi Takizawa, Toshio Suda. The analysis, roles and regulation of quiescence in hematopoietic stem cells. DEVELOPMENT. 2014. 141. 24. 4656-4666
  • Ayako Nakamura-Ishizu, Toshio Suda. Not merely quiescent: telomeres in quiescent HSCs. BLOOD. 2014. 124. 22. 3179-3180
学歴 (2件):
  • 2005 - 2009 Tokyo Women't Medical University School of Medicine Graduate program
  • 1996 - 2002 Tokyo Women's Medical Univesity School of Medicine Medicine
学位 (1件):
  • 博士(医学) (東京女子医科大学)
経歴 (2件):
  • 2013/07 - 2019/06 National University of Singapore Cancer Science Institute Senior Research Scientist
  • 2009/03 - 2013/06 Keio University Medicine, Dept Cell Differentiation Post-doctorate researcher
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