河部剛史

カワベタケシ | Kawabe Takeshi

所属機関・部署：
職名：准教授

研究分野 (1件)：免疫学

研究キーワード (3件)：感染免疫 , 自己免疫・炎症性疾患 , T細胞

競争的資金等の研究課題 (8件)：

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論文 (29件)：

Kawabe T. Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes. Immunol Med. 2023. 46. 1. 1-8
Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N. IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling. Biochem Biophys Res Commun. 2022. 637. 9-16
Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, et al. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol. 2022. 7. 76. eabm9811
Kawabe T. Memory-phenotype CD4+ T Lymphocytes: A Novel Therapeutic Target in Infectious or Autoimmune Diseases?. JMA J. 2022. 5. 3. 298-306
Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, et al. Redefining the Foreign Antigen and Self-Driven Memory CD4+ T-Cell Compartments via Transcriptomic, Phenotypic, and Functional Analyses. Front Immunol. 2022. 13. 870542

MISC (18件)：

Kawabe T, Ciucci T, Kim KS, Yang Z, Kawajiri A, Tayama S, Ishii N, Jankovic D, Zhu J, Sprent J, et al. CD127 and Sca1 mark self-driven memory-phenotype CD4 +T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities. J Immunol. 2023. 210. S1. 76.08
Kawajiri A, Li J, Yang Z, Koinuma K, Yoon HJ, Ishii M, Tayama S, Sato K, Okuyama Y, Harigae H, et al. Self antigen-driven, undifferentiated memory-phenotype CD4 T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells. J Immunol. 2023. 210. S1. 76.09
Tayama S, Kitamura Y, Hiraide K, Li J, Yang Z, Kawajiri A, Sato K, Okuyama Y, Kawabe T, Akaike T, et al. Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation. J Immunol. 2023. 210. S1. 61.01
Takeshi Kawabe, Jaeu Yi, Akihisa Kawajiri, Kerry Hilligan, Difeng Fang, Naoto Ishii, Hidehiro Yamane, Jinfang Zhu, Dragana Jankovic, Kwang Soon Kim, et al. Author Correction: Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state (Nature Communications, (2020), 11, 1, (3366), 10.1038/s41467-020-17136-1). Nature Communications. 2020. 11. 1
田山舜一, 河部剛史, 石井直人. 2型自然リンパ球における足場蛋白質IQGAP1の新たな役割. 臨床免疫・アレルギー科. 2020. 74. 3. 226-233

書籍 (2件)：

講演・口頭発表等 (73件)：

Self-driven memory-phenotype cells: a naturally arising CD4+ T lymphocyte population possessing innate immune function
(The RIKEN IMS-JSI International Symposium on Immunology 2023 2023)
Reactive persulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation
(Annual Meeting of The American Association of Immunologists 2023 2023)
CD127 and Sca1 mark self-driven memory-phenotype CD4+ T cells that differ from foreign antigen-specific memory cells and possess inflammatogenic and anti-tumor activities
(Annual Meeting of The American Association of Immunologists 2023 2023)
Self antigen-driven, undifferentiated memory-phenotype CD4+ T lymphocytes can induce mild and systemic inflammation by differentiating into effector and regulatory T cells
(Annual Meeting of The American Association of Immunologists 2023 2023)
新規の自然免疫型T細胞の機能制御による新たな感染症治療戦略の創出
(第6回先進医薬研究報告会 2022)

学歴 (2件)：

学位 (1件)：

経歴 (6件)：

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受賞 (17件)：

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所属学会 (2件)：

International Cytokine and Interferon Society , 日本免疫学会

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河部 剛史