研究者
J-GLOBAL ID：201801015387571464   更新日: 2024年10月01日

増田 光治

MASUDA Mitsuharu
所属機関・部署：
京都府立医科大学 分子標的予防医学

京都府立医科大学 分子標的予防医学 について


職名： 助教
研究分野 (1件)： 分子生物学
競争的資金等の研究課題 (5件)：
  • 2019 - 2021 RB活性化能を有するがん予防成分を応用した動脈硬化予防戦略
  • 2018 - 2021 がん抑制遺伝子の異常を狙い撃つ、新たながん予防戦略
  • 2015 - 2019 がんの「分子標的予防法」のヒト予防介入試験への応用
  • 2015 - 2017 がん予防介入研究における喫煙による増悪機序の解明
  • 2013 - 2015 分子標的癌予防の実用化に向けて;安全かつ効果的な癌予防ジュースの創製の試み
論文 (23件)：
  • Yosuke Ota, Yukihiro Itoh, Yuri Takada, Yasunobu Yamashita, Chenliang Hu, Mano Horinaka, Yoshihiro Sowa, Mitsuharu Masuda, Toshiyuki Sakai, Takayoshi Suzuki. Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells. Bioorganic & medicinal chemistry. 2024. 100. 117632-117632
  • Yukihiro Itoh, Peng Zhan, Toshifumi Tojo, Pattaporn Jaikhan, Yosuke Ota, Miki Suzuki, Ying Li, Zi Hui, Yukiko Moriyama, Yuri Takada, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of medicinal chemistry. 2023. 66. 22. 15171-15188
  • Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental health and preventive medicine. 2023. 28. 54-54
  • Yosuke Ota, Yukihiro Itoh, Takashi Kurohara, Ritesh Singh, Elghareeb E Elboray, Chenliang Hu, Farzad Zamani, Anirban Mukherjee, Yuri Takada, Yasunobu Yamashita, et al. Cancer-Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS medicinal chemistry letters. 2022. 13. 10. 1568-1573
  • Motoki Watanabe, Shogen Boku, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, et al. A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. PNAS nexus. 2022. 1. 2. pgac059
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MISC (28件)：
  • 増田 光治, 堀中 真野, 安田 周祐, 森田 美枝, 西幹 栄美, 石川 秀樹, 武藤 倫弘, 酒井 敏行. RB再活性化ジュースの発見(Discovery of RB-reactivating juices). 日本癌学会総会記事. 2023. 82回. 1439-1439
  • Itoh, Yukihiro, Zhan, Peng, Tojo, Toshifumi, Jaikhan, Pattaporn, Ota, Yosuke, Suzuki, Miki, Li, Yin, Hui, Zi, Moriyama, Yukiko, Oba, Makoto, et al. Discovery of Selective Histone Deacetylase 1 and 2 Inhibitors: Screening of a Focused Library Constructed by Click Chemistry, Kinetic Binding Analysis, and Biological Evaluation. Journal of Medicinal Chemistry. 2023
  • Mitsuharu Masuda, Mano Horinaka, Shusuke Yasuda, Mie Morita, Emi Nishimoto, Hideki Ishikawa, Michihiro Mutoh, Toshiyuki Sakai. Discovery of cancer-preventive juices reactivating RB functions. Environmental Health and Preventive Medicine. 2023. 28. 54-54
  • Motoki Watanabe, Shogen Boku, Kaito Kobayashi, Yoichi Kurumida, Mamiko Sukeno, Mitsuharu Masuda, Katsura Mizushima, Chikage Kato, Yosuke Iizumi, Kiichi Hirota, et al. A chemoproteoinformatics approach demonstrates that aspirin increases sensitivity to MEK inhibition by directly binding to RPS5. PNAS Nexus. 2022. 1. 2
  • Ota, Yosuke, Itoh, Yukihiro, Kurohara, Takashi, Singh, Ritesh, Elboray, Elghareeb, Hu, Chenliang, Zamani, Farzad, Mukherjee, Anirban, Takada, Yuri, Yamashita, Yasunobu, et al. Cancer Cell-Selective Targeting by Arylcyclopropylamine-Vorinostat Conjugates. ACS Medicinal Chemistry Letters. 2022
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