林剛瑠

ハヤシタケル | Hayashi Takeru

所属機関・部署：
職名：主任研究員
ホームページURL (1件)： https://www.bikaken.or.jp/

研究分野 (3件)：腫瘍生物学 , 構造生物化学 , 細菌学

研究キーワード (4件)：胃がん , ピロリ菌 , CagA , ハイスループットスクリーニング

競争的資金等の研究課題 (5件)：

論文 (17件)：

Junya Arai, Yoku Hayakawa, Hiroaki Tateno, Keita Murakami, Takeru Hayashi, Masahiro Hata, Yuki Matsushita, Hiroto Kinoshita, Sohei Abe, Ken Kurokawa, et al. Impaired Glycosylation of Gastric Mucins Drives Gastric Tumorigenesis and Serves as a Novel Therapeutic Target. Gastroenterology. 2024
Takeru Hayashi, Masanori Hatakeyama. Exploring Allosteric Inhibitors of Protein Tyrosine Phosphatases Through High-Throughput Screening. Methods in Molecular Biology. 2023. 2691. 235-245
Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama. Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization. International Journal of Molecular Sciences. 2022. 23. 12. 6634-6634
Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Takeru Hayashi, Masanori Hatakeyama. Alternative splicing reverses the cell-intrinsic and cell-extrinsic prooncogenic potentials of YAP1. The Journal of biological chemistry. 2020
Hashi K, Imai C, Yahara K, Tahmina K, Hayashi T, Azuma T, Miyabe-Nishiwaki T, Sato H, Matsuoka M, Niimi S, et al. Evaluating the origin and virulence of a Helicobacter pylori cagA-positive strain isolated from a non-human primate. Scientific reports. 2018. 8. 1. 15981-15981

MISC (10件)：

講演・口頭発表等 (17件)：

Structure-function analysis for deregulation of SHP2 by geographically distinct variants of Helicobacter pylori CagA
(The 37th Sapporo International Cancer Symposium 2018)
ピロリ菌CagAによる細胞内シグナル撹乱の構造生物学的解析
(マックスプランク・東京大学統合炎症学センタージュニアフェローセミナー 2017)
Structural and functional mechanisms underlying activation of SHP2 by geographically distinct Helicobacter pylori CagA oncoproteins
(Europhosphatase 2017: Phosphatases in cell fates and decisions 2017)
Structural insights into the mechanism underlying activation of SHP2 by the Helicobacter pylori CagA oncoprotein
(第75回日本癌学会学術総会 2016)
Biochemical and biophysical analysis for the interaction of Helicobacter pylori CagA oncoprotein with Csk
(第73回日本癌学会学術総会 2014)

学歴 (2件)：

学位 (1件)：

経歴 (3件)：

委員歴 (1件)：

2021/09 - 現在 Editorial board of Frontiers in Oncology (Molecular and Cellular Oncology) Review Editor

受賞 (1件)：

所属学会 (2件)：

日本分子生物学会 , 日本癌学会

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林 剛瑠