Hiroyuki Yamakoshi, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi. Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction. Chemical and Pharmaceutical Bulletin. 2024. 72. 1. 127-134
Aki Kohyama, Aya Shiuchi, Yue Zhou, Masaru Tanioka, Kenji Sugimoto, Hiroaki Sakurai, Yuji Matsuya. Controllable conformation and reactivity of bicyclic α-methylene cyclopentanones and their NF-κB pathway inhibitory activity. Organic & Biomolecular Chemistry. 2023. 21. 22. 4656-4660
Hiroyuki Yamakoshi, Daiki Shibata, Kazuki Bando, Shinji Kajimoto, Aki Kohyama, Syusuke Egoshi, Kosuke Dodo, Yoshiharu Iwabuchi, Mikiko Sodeoka, Katsumasa Fujita, et al. Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy. Chemical Communications. 2023. 59. 98. 14563-14566
Aki Kohyama, Min Jo Kim, Rei Yokoyama, Sijia Sun, Ashraf M Omar, Nguyen Duy Phan, Meselhy R Meselhy, Kiyoshi Tsuge, Suresh Awale, Yuji Matsuya. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorganic & medicinal chemistry. 2022. 54. 116563-116563
Amira A Abdellatef, Yue Zhou, Akane Yamada, Sahar A Elmekkawy, Aki Kohyama, Satoru Yokoyama, Meselhy R Meselhy, Yuji Matsuya, Hiroaki Sakurai, Yoshihiro Hayakawa. Synthetic E-guggulsterone derivative GSD-1 inhibits NF-κB signaling and suppresses the metastatic potential of breast cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021. 140. 111737-111737