研究者
J-GLOBAL ID：201901007342412386   更新日: 2024年11月01日

ナスティ アレッサンドロ

Alessandro Nasti
所属機関・部署：
国立大学法人金沢大学 医薬保健学総合研究科 情報医学開発講座

国立大学法人金沢大学 医薬保健学総合研究科 情報医学開発講座 について


職名： 特任准教授
研究分野 (3件)： その他 ,  腫瘍診断、治療学 ,  免疫学
研究キーワード (6件)： Blood transcriptomics ,  Pancreatic ductal adenocarcinoma (PDAC) ,  Hepatitis ,  Immunotherapy ,  Adult stem/stromal adipose tissue-derived cells (ADSCs) ,  Regenerative therapy
競争的資金等の研究課題 (7件)：
  • 2024 - 2029 Proton radiation therapy combined with immunotherapy for enhancing antitumor immune responses in pancreatic cancer murine models.
  • 2024 - 2025 陽子線がん治療の高度化
  • 2022 - 2024 陽子線がん治療の高度化
  • 2022 - 2023 Bispecific抗体を用いた膵癌免疫療法の開発
  • 2020 - 2023 Study of liver restorative therapy for a murine nonalcoholic steatohepatitis model by the administration of immune-suppressive fractions of autologous adipose tissue-derived stromal cells
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論文 (24件)：
  • Alessandro Nasti, Miki Okumura, Yumie Takeshita, Tuyen Thuy Bich Ho, Yoshio Sakai, Taka-Aki Sato, Chiaki Nomura, Hisanori Goto, Yujiro Nakano, Takeshi Urabe, et al. The declining insulinogenic index correlates with inflammation and metabolic dysregulation in non-obese individuals assessed by blood gene expression. Diabetes Research and Clinical Practice. 2024. 111090-111090
  • 奥村 美輝, 竹下 有美枝, 喜多 裕樹, 野村 千晶, 船崎 友馨, 田中 健雄, 後藤 久典, 中野 雄二郎, Alessandro Nasti, 酒井 佳夫, et al. 8年後のインスリン分泌能を予知しうるバイオマーカー. 糖尿病. 2023. 66. Suppl.1. S-182
  • Alessandro Nasti, Masaki Miyazawa, Akihiro Seki, Tuyen Thuy Bich Ho, Riei Tsurumi, Miu Awaki, Yoshio Sakai, Shuichi Kaneko. Bioinformatics Methods for the Identification of Treatment Response Prediction Markers in Pancreatic Cancer. SoMeT. 2023. 1-11
  • Akihiro Seki, Yoshio Sakai, Alessandro Nasti, Norihiko Ogawa, Eishiro Mizukoshi. In Abstracts: (2425) Mesenchymal stromal cells restore the NASH by ameliorating ER stress of hepatocytes derived from hepatic stellate cells. Hepatology. 2022. 76. S1. S1-S1564
  • Masaaki Yano*, Alessandro Nasti*, Akihiro Seki, Kosuke Ishida, Masatoshi Yamato, Hiiro Inui, Norihiko Ogawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Kazunori Kawaguchi, et al. Characterization of adipose tissue-derived stromal cells of mice with nonalcoholic fatty liver disease and their use for liver repair. Regenerative therapy. 2021. 18. 497-507
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MISC (18件)：
  • Alessandro NASTI, 関晃裕, 里村康輔, Tuyen Thuy Bich HO, 酒井佳夫, 小川憲彦, 稲垣慎吾, 宮澤正樹, 野村浩樹, 久米恭, et al. 陽子線治療に伴う癌免疫応答の解明と新規免疫放射線療法の開発. 若狭湾エネルギー研究センター研究年報. 2024. 26. 12-13
  • Alessandro NASTI, 酒井佳夫, 小川憲彦, Tuyen Thuy Bich HO, 宮澤正樹, 稲垣慎吾, 関晃裕, 山下太郎, 里村康輔, 野村浩樹, et al. 陽子線治療に伴うがん免疫応答の解明と新規免疫放射線療法の開発. 若狭湾エネルギー研究センター研究年報. 2023. 25. L6940A. 11-12
  • 酒井佳夫, NASTI Alessandro, HO Tuyen Thuy Bich, 小川憲彦, 宮澤正樹, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. 陽子線治療に伴うがん免疫応答の解明と新規免疫放射線療法の開発. 若狭湾エネルギー研究センター研究年報. 2022. 24
  • 酒井佳夫, NASTI Alessandro, 小川憲彦, 宮澤正樹, HO Tuyen Thuy Bich, 関晃裕, 稲垣慎吾, 野村博樹, 久米恭, 前田宗利, et al. 陽子線治療に伴う癌免疫応答の解明と新規免疫放射線療法の開発. 若狭湾エネルギー研究センター研究年報. 2021. 23
  • Alessandro Nasti, Yoshio Sakai, Norihiko Ogawa, Masaki Miyazawa, Shingo Inagaki, Tuyen Thuy Bich Ho, Hiroki Nomura, Akihiro Seki, Kyo Kume, Munetoshi Maeda, et al. Antitumor effect of proton beam irradiation and anti-PD-L1 antibody combination therapy in subcutaneous murine models of pancreatic cancer. European Journal of Immunology. 2021. 51 (Suppl. 1). 1-448
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特許 (4件)：
  • 膵癌・胆道系癌の化学療法剤の奏効性予測マーカー、及びそれに対応する奏効性予測キット
  • 癌免疫増強剤、及びそれを含有する増強抗癌剤
  • 幹細胞の製造方法
  • Pharmaceutical compositions based on porous zeolites as release means of pharmacologically active molecules and relative use.
書籍 (4件)：
  • BIOINFORMATIC ANALYSIS OF BLOOD GENE EXPRESSION FOR COMBINATION IMMUNOTHERAPY EVALUATION IN MURINE MODEL OF PANCREATIC CANCER
    World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
  • BIOINFORMATICS METHODS FOR THE CHARACTERIZATION OF MURINE ADIPOSE-TISSUE DERIVED STROMAL CELLS ALTERED BY CONTINUOUS ROTATION SUSPENSION
    World Research Library, Proceedings of ResearchWorld International Conference, Rome, Italy, 25th - 26th September 2023 2023
  • マウス脂肪組織由来ストローマ細胞におけるCD45+分画には,免疫抑制性炎症細胞が存在する
    2018
  • Thesis: Chitosan-based nanoparticles and microparticles
    2008
講演・口頭発表等 (61件)：
  • Combination therapy of proton beam irradiation and PD-L1 inhibitor induced an immune response in murine models of pancreatic cancer
    (The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
  • Cystatin A enhances CD4+ T cells and M1 macrophages antitumor activity in murine models of pancreatic cancer
    (The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
  • Cystatin A enhances CD4+ T cells and M1 macrophages antitumor activity in murine models of pancreatic cancer
    (The 53rd Annual Meeting of the Japanese Society for Immunology (JSI2024) 2024)
  • Immune response evaluation in pancreatic cancer mouse models following proton beam irradiation and anti-PD-L1 immunotherapy
    (The 47th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2024) 2024)
  • Blood gene expression assessed in non-obese individuals confirms the link between declining insulinogenic index, inflammation and metabolic dysregulation
    (The 47th Annual Meeting of the Molecular Biology Society of Japan (MBSJ2024) 2024)
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学歴 (6件)：
  • 2011 - 2018 Kanazawa University Graduate School of Medical Science. Department of Graduate School of Advanced Preventive Medical Sciences (System Biology), Kanazawa, Japan PhD in Medical Sciences
  • 2006 - 2008 The University of Manchester School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Doctoral study exchange programme
  • 2005 - 2008 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy PhD in Medicinal Chemistry
  • 1999 - 2004 Università degli Studi di Napoli Federico II Faculty of Pharmacy, Napoli, Italy Master of Sciences of Pharmacy (MPharm)
  • 2002 - 2003 Procter & Gamble Italian Research Center, Pescara, Italy Research Internship
全件表示
学位 (3件)：
  • PhD in Medical Sciences (Kanazawa University; Kanazawa, JAPAN)
  • PhD in Medicinal Chemistry (University of Naples Federico II; Naples, ITALY)
  • Master in Pharmacy (University of Naples Federico II; Naples, ITALY)
経歴 (3件)：
  • 2011/10 - 現在 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences; System Biology, Kanazawa, Japan Engaged in the research of immunotherapies for the diseases of the gastrointestinal tract: specifically for liver and intestinal diseases. Postdoctoral Researcher
  • 2009/05 - 2011/09 Lincoln County Hospital, UK National Health Service (NHS), Lincoln, UK Provided service to wards and departments, exercised professional supervision over clinical use of drugs in patients. Rotational Clinical Pharmacist
  • 2009/03 - 2009/04 The University of Manchester, School of Pharmacy and Pharmaceutical Sciences. Laboratory of Polymers and Biomaterials, Manchester, UK Support and supervision of PhD students. Focused on the preparation of biocompatible nanoparticles and microparticles for drug delivery. Honorary Research Associate
委員歴 (1件)：
  • 2024/07 - 現在 Association of Italian Researchers in Japan (AIRJ) AIRJ Board
受賞 (1件)：
  • 2021/02 - 金沢大学 Papers of the Monthプロ ジェクト 膵癌肝転移マウスモデルに対する化学療法併用の有効性を解明 〜 膵臓がんの効果的な化学療法の確立へ向けて 〜
所属学会 (3件)：
一般財団法人日本消化器病学会 ,  在日イタリア人研究者協会 ,  日本免疫学会
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