研究者
J-GLOBAL ID：202001006214255418   更新日: 2024年11月20日

奥山 一生

Okuyama Kazuki
競争的資金等の研究課題 (3件)：
  • 2020 - 2023 BCL11B変異によるヒト原発性免疫不全症発症機序の解明
  • 2014 - 2016 NOTCH1抑制性miRNAによるT細胞性リンパ芽球性白血病治療
  • 2010 - 2011 B細胞、T細胞分化をモデルとした、細胞分化・運命決定機構の解析
論文 (24件)：
  • Kazuki Okuyama, Motoi Yamashita, Artemis Koumoundourou, Christoph Wiegreffe, Michiko Ohno-Oishi, Samuel J H Murphy, Xin Zhao, Hideyuki Yoshida, Takashi Ebihara, Naoko Satoh-Takayama, et al. A mutant BCL11B-N440K protein interferes with BCL11A function during T lymphocyte and neuronal development. Nature immunology. 2024
  • Kazuki Okuyama, Aneela Nomura, Kohei Nishino, Hirokazu Tanaka, Christelle Harly, Risa Chihara, Yasuyo Harada, Sawako Muroi, Masato Kubo, Hidetaka Kosako, et al. The Majority of the Serine/Threonine Phosphorylation Sites in Bcl11b Protein Are Dispensable for the Differentiation of T Cells. The Journal of Immunology. 2023. 210. 11. 1728-1739
  • 幸谷 愛, 黒崎 なつみ, 長島 悦子, 奥山 一生, 山川 奈津子, 緒方 洵, 樋口 廣士, 川島 雅晴, 宮竹 佑治, 亀田 和明, et al. 悪性リンパ増殖疾患における腫瘍微小環境形成過程の究明とその制御による治療法開発(Investigation of tumor microenvironment formation in lymphoproliferative diseases and development of treatment). 日本癌学会総会記事. 2022. 81回. JWAS-1
  • Motoi Yamashita, Hye Sun Kuehn, Kazuki Okuyama, Satoshi Okada, Yuzaburo Inoue, Noriko Mitsuiki, Kohsuke Imai, Masatoshi Takagi, Hirokazu Kanegane, Masahiro Takeuchi, et al. A variant in human AIOLOS impairs adaptive immunity by interfering with IKAROS. Nature immunology. 2021. 22. 7. 893-903
  • Masaharu Kawashima, Joaquim Carreras, Hiroshi Higuchi, Ryutaro Kotaki, Takahiro Hoshina, Kazuki Okuyama, Naoto Suzuki, Masatoshi Kakizaki, Yuji Miyatake, Kiyoshi Ando, et al. PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma. Leukemia. 2020. 34. 9. 2405-2417
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MISC (8件)：
  • 那須 亮, 奥山 一生, 扇屋 大輔, 穂積 勝人, 村田 暁彦, 安藤 潔, 幸谷 愛. 新たに同定されたNotchを標的とするmiRNAによるB細胞分化の制御とT-ALL治療の可能性. 日本癌学会総会記事. 2015. 74回. P-1137
  • Ai Sato, Natsuko Yamakawa, Kazuki Okuyama, Ai Kotani, Naoya Nakamura, Kiyoshi Ando. The Critical Interaction Between Epstein-Barr Virus (EBV) Positive B-Cells and Tumor Associated Macrophages (TAMs). BLOOD. 2014. 124. 21
  • Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21
  • Bidisha Chanda, Tomokatsu Ikawa, Kazuki Okuyama, Katsuto Hozumi, Kiyoshi Ando, Arinobu Tojo, Hiroshi Kawamoto, Ai Kotani. EBF Deficient Hematopoietic Progenitor Cells Potentialy Differentiated into Immature B Cell: EBF1 Dispensable for B Cell Linage Commitment from Pro-B to Pre-B Stage. BLOOD. 2014. 124. 21
  • Bidisha Chanda, Jun Ogata, Tomokatsu Ikawa, Kazuki Okuyama, Kiyoshi Ando, Arinobu Tojo, Ai Kotani. A Single Micro-RNA Can Completely Rescue B-Cell Differentiation Arrest Due To EBF1 Deficiency: Can Micro-RNA Control Cell Fate As a Potential Alternative Of Transcriptional Factor?. BLOOD. 2013. 122. 21
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