研究者
J-GLOBAL ID：202001010113454921
更新日: 2024年04月19日
ミトワリー ホザイファ
Metwally Hozaifa | Metwally Hozaifa
所属機関・部署：
研究キーワード (1件)：
gene regulation, host defense, infection, inflammation
競争的資金等の研究課題 (1件)：
- 2019 - 2021 Unveiling Novel STAT1 Activation Expands its Anti-viral Role into Host Defense Against Bacterial Pathogens
論文 (11件)：
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Hozaifa Metwally, Maha M Elbrashy, Tatsuhiko Ozawa, Kazuki Okuyama, Jason T White, Janyerkye Tulyeu, Jonas Nørskov Søndergaard, James Badger Wing, Arisa Muratsu, Hisatake Matsumoto, et al. Threonine phosphorylation of STAT1 restricts interferon signaling and promotes innate inflammatory responses. Proceedings of the National Academy of Sciences of the United States of America. 2024. 121. 17. e2402226121
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Kishan Kumar Nyati, Shigeru Hashimoto, Shailendra Kumar Singh, Murat Tekguc, Hozaifa Metwally, Yu-Chen Liu, Daisuke Okuzaki, Yohannes Gemechu, Sujin Kang, Tadamitsu Kishimoto. The novel long noncoding RNA AU021063, induced by IL-6/Arid5a signaling, exacerbates breast cancer invasion and metastasis by stabilizing Trib3 and activating the Mek/Erk pathway. Cancer Letters. 2021. 520. 295-306
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Gyanu Parajuli, Murat Tekguc, James B. Wing, Ari Hashimoto, Daisuke Okuzaki, Takeshi Hirata, Atsushi Sasaki, Takahide Itokazu, Haruka Handa, Hirokazu Sugino, et al. Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression. Cancer Immunology Research. 2021. 9. 8. 862-876
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The Yin and the Yang of STAT1 Downstream of TLR4 Endocytosis: STAT1 beyond Interferon Signaling. Journal of Cellular Immunology. 2020. 2. 5
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Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties. Journal of Cellular Signaling. 2020. 1. 3
もっと見る
MISC (1件)：
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Hozaifa Metwally, Toshio Tanaka, Tadamitsu Kishimoto. Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNy-sensitized human macrophages.'. JOURNAL OF IMMUNOLOGY. 2017. 198. 1
講演・口頭発表等 (3件)：
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STAT1 displays functionally distinct phosphorylation upon LPS stimulation
(The 45th IFReC Colloquium 2020)
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STAT1 DISPLAYS FUNCTIONALLY DISTINCT PHOSPHORYLATION UPON LPS STIMULATION
(7th Annual Meeting of the International Cytokine & Interferon Society, Vienna 2019 2019)
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Arid5a expression is induced through MYD88-independent pathway in response to TLR4 stimulation in IFNγ-sensitized human macrophages
(The 7th NIF Winter School on Advanced Immunology, Awajii island, Japan 2018 2018)
学歴 (2件)：
- 2015 - 2018 Graduate School of Frontier Biosciences, Osaka University PhD
- 2007 - 2015 Faculty Of Medicine, Suez Canal University MD
学位 (2件)：
- PhD (大阪大学)
- MBBCh (Suez Canal University)
経歴 (4件)：
- 2022/04 - 現在 大阪大学 免疫学フロンティア研究センター
- 2020/05 - 2022/03 大阪大学 免疫学フロンティア研究センター
- 2019/01 - 2020/04 大阪大学 免疫学フロンティア研究センター
- 2015/11 - 2018/12 大阪大学 免疫学フロンティア研究センター
受賞 (1件)：
- 2019/10 - The International Cytokine & Interferon Society Milstein Travel Award
所属学会 (2件)：
International Cytokine & Interferon Society (ICIS)
, American Association of Immunologists (AAI)
