橋本拓哉

Hashimoto Takuya

競争的資金等の研究課題 (2件)：

2020 - 2022 遠縁種間の微生物二次代謝産物生産を可能にする人工生合成遺伝子の創製
2018 - 2020 200 kbを越す超巨大生合成遺伝子クラスターを利用した化合物生産法の確立

論文 (11件)：

Takuya Hashimoto, Hikaru Suenaga, Keita Amagai, Junko Hashimoto, Ikuko Kozone, Shunji Takahashi, Kazuo Shin-Ya. In Vitro Module Editing Of NRPS Enables Production Of Highly Potent Gq -Signaling Inhibitor FR900359 Derived From Unculturable Plant Symbiont. Angewandte Chemie (International ed. in English). 2024. e202317805
Takuya Hashimoto, Junko Hashimoto, Noritaka Kagaya, Takehiro Nishimura, Hikaru Suenaga, Makoto Nishiyama, Tomohisa Kuzuyama, Kazuo Shin-ya. A novel oxazole-containing tetraene compound, JBIR-159, produced by heterologous expression of the cryptic trans-AT type polyketide synthase biosynthetic gene cluster. The Journal of Antibiotics. 2021. 74. 5. 354-358
Reiko Ueoka, Junko Hashimoto, Ikuko Kozone, Takuya Hashimoto, Kei Kudo, Noritaka Kagaya, Hikaru Suenaga, Haruo Ikeda, Kazuo Shin-Ya. A novel methymycin analog, 12-ketomethymycin N-oxide, produced by the heterologous expression of the large pikromycin/methymycin biosynthetic gene cluster of Streptomyces sp. AM4900. Bioscience, biotechnology, and biochemistry. 2021. 85. 4. 890-894
Kei Kudo, Takuya Hashimoto, Junko Hashimoto, Ikuko Kozone, Noritaka Kagaya, Reiko Ueoka, Takehiro Nishimura, Mamoru Komatsu, Hikaru Suenaga, Haruo Ikeda, et al. In vitro Cas9-assisted editing of modular polyketide synthase genes to produce desired natural product derivatives. Nature Communications. 2020. 11. 1. 4022-4022
Takuya Hashimoto, Ikuko Kozone, Junko Hashimoto, Hikaru Suenaga, Manabu Fujie, Noriyuki Satoh, Haruo Ikeda, Kazuo Shin-ya. Identification, cloning and heterologous expression of biosynthetic gene cluster for desertomycin. The Journal of Antibiotics. 2020. 73. 9. 650-654

MISC (1件)：

橋本拓哉, 葛山智久. [4+2]-環化付加反応によるポリケタイド大環状化機構の発見. バイオサイエンスとインダストリー. 2015. 73. 5. 380-382

※　J-GLOBALの研究者情報は、researchmapの登録情報に基づき表示しています。登録・更新については、こちらをご覧ください。

前のページに戻る

橋本 拓哉

橋本拓哉