橋本洋佑

ハシモトヨウスケ | Hashimoto Yosuke

所属機関・部署：

研究分野 (1件)：薬系衛生、生物化学

研究キーワード (4件)： Blood-brain barrier , Tight junction , Claudin-5 , Monoclonal antibody

競争的資金等の研究課題 (5件)：

2020 - 2021 Genome-wide screening to discover novel claudin-5 regulating genes for establishing the strategy to normalize the permeability of blood-brain barrier
2019 - 2020 血液脳関門の細胞間隙透過性亢進時における脳内微小環境のイメージング
2017 - 2020 Tight-junction binderによる革新的血液脳関門制御技術の開発
2019 - 2020 抗claudin-5抗体による革新的な血液脳関門制御技術の確立
2015 - 2017 Claudin-5 binderによる薬物脳内移行性向上戦略の確立

論文 (20件)：

Yosuke Hashimoto, Claude Besmond, Nathalie Boddaert, Arnold Munnich, Matthew Campbell. A loss of function mutation in CLDN25 causing Pelizaeus-Merzbacher-like leukodystrophy. Human Molecular Genetics. 2024
Yosuke Hashimoto, Karine Poirier, Nathalie Boddaert, Laurence Hubert, Melodie Aubart, Anna Kaminska, Marianne Alison, Isabelle Desguerre, Arnold Munnich, Matthew Campbell. Recurrent de novo mutations in CLDN5 induce an anion-selective blood-brain barrier and alternating hemiplegia. Brain. 2022. 145. 10. 3374-3382
Keisuke Tachibana, Yosuke Hashimoto, Keisuke Shirakura, Yoshiaki Okada, Ryuichi Hirayama, Yumi Iwashita, Itsuki Nishino, Yukio Ago, Hiroyuki Takeda, Hiroki Kuniyasu, et al. Safety and efficacy of an anti-claudin-5 monoclonal antibody to increase blood-brain barrier permeability for drug delivery to the brain in a non-human primate. Journal of Controlled Release. 2021. 336. 105-111
Taro Shimizu, Amr S Abu Lila, Yoshino Kawaguchi, Yuna Shimazaki, Yuki Watanabe, Yu Mima, Yosuke Hashimoto, Keiichiro Okuhira, Gert Storm, Yu Ishima, et al. A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes. Journal of immunology (Baltimore, Md. : 1950). 2018. 201. 10. 2969-2976
Taro Shimizu, Amr S Abu Lila, Mizuki Awata, Yukiyo Kubo, Yu Mima, Yosuke Hashimoto, Hidenori Ando, Keiichiro Okuhira, Yu Ishima, Tatsuhiro Ishida. A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics. Pharmaceutical research. 2018. 35. 11. 223-223

MISC (15件)：

Yosuke Hashimoto. Claudin-5を創薬標的とする研究. Drug Delivery System. 2023. 38. 3. 254-255
Yosuke Hashimoto, Chris Greene, Arnold Munnich, Matthew Campbell. The CLDN5 gene at the blood-brain barrier in health and disease. Fluids and barriers of the CNS. 2023. 20. 22
Isabelle Desguerre, Melodie Aubart, Yosuke Hashimoto, Karine Poirier, Anna Kaminska, Marianne Alison, Nathalie Boddaert, Arnold Munnich, Matthew Campbell. Reply: De novo mutations in CLDN5: alternating hemiplegia of childhood or not?. Brain : a journal of neurology. 2023
Yosuke Hashimoto, Matthew Campbell, Keisuke Tachibana, Yoshiaki Okada, Masuo Kondoh. Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier. Biological and Pharmaceutical Bulletin. 2021. 44. 10. 1380-1390
橋本洋佑. アイルランドでの研究生活. 製剤機械技術学会誌 = Journal of pharmaceutical machinery and engineering. 2021. 30. 1. 57-59

特許 (2件)：

Claudin 5抗体、及びその抗体を含有する医薬
抗CLDN-5抗体、及びその抗体を含有する医薬

講演・口頭発表等 (9件)：

Identification of novel negative regulators of blood retina barrier integrity by genome-wide screening; Relevance to novel treatments for age-related macular degeneration
(XXth INTERNATIONAL SYMPOSIUM ON RETINAL DEGENERATION RD2023)
A novel de novo missense mutation in CLDN5 found in patients with alternating hemiplegia of childhood
(5th Mini-symposium on the blood-brain barrier From basic to clinical research 2023)
Discovery of a novel pathogenic de novo CLDN5 mutation associated with alternating hemiplegia of childhood
(12th UK and Ireland Early Career BBB Symposium 2022)
Functional analysis of a novel pathogenic de novo CLDN5 mutation asscoiated with alternating hemiplegia
(24th International symposium on signal transduction at the blood-brain barriers)
Pumilios-mediated translational control of claudin-5
(Gordon Research Seminar/Conference, Barriers of the CNS)

学歴 (3件)：

2014 - 2017 大阪大学大学院薬科学研究科
2012 - 2014 徳島大学大学院薬科学教育部
2008 - 2012 徳島大学薬学部創製薬科学科

経歴 (6件)：

2022/10 - 現在 Trinity College Dublin Smurfit Institute of Genetics Post-doc
2020/04 - 2022/09 日本学術振興会海外特別研究員
2019/07 - 2022/09 Trinity College Dublin Smurfit Institute of Genetics Visiting Researcher
2017/04 - 2020/03 日本学術振興会特別研究員(PD)
2017/04 - 2019/06 名古屋大学環境医学研究所研究員

全件表示

受賞 (4件)：

2023/10 - The XXth International Symposium on Retinal Degenerations (RD2023) and the BrightFocus Macular Fast Track A Travel Award to the RD2023 meeting
2014/01 - 徳島大学康楽賞奨学生の部
2013/11 - 第35回生体膜と薬物の相互作用シンポジウム優秀発表者賞 siRNA搭載PEG修飾リポプレックス投与時に誘起される抗PEG IgM分泌亢進機構の解明
2012/05 - 永井記念薬学国際交流財団日本薬剤学会永井財団大学院学生スカラシップ

所属学会 (3件)：

日本薬剤学会 , 日本薬学会 , 日本DDS学会

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橋本 洋佑

橋本洋佑