研究者
J-GLOBAL ID:202101012518755490   更新日: 2024年07月17日

ツァン ケム

ツァン ケム | Zhang Kam
所属機関・部署:
職名: チームリーダー
研究分野 (2件): 生命、健康、医療情報学 ,  構造生物化学
研究キーワード (5件): Virtual screening ,  Drug design ,  Protein design ,  Structure prediction ,  Protein folding
競争的資金等の研究課題 (3件):
  • 2018 - 2021 非天然アミノ酸の取り込みによる安定かつ高親和性の治療用ナノボディの設計
  • 2018 - 2021 タンパク質の構造設計の計算方法の研究開発および実験検証
  • 2016 - 2019 アルツハイマー病治療のためのヒトグルタミニルシクラーゼ阻害剤の探索
論文 (115件):
  • Johannes Schimunek, Philipp Seidl, Katarina Elez, Tim Hempel, Tuan Le, Frank Noé, Simon Olsson, Lluís Raich, Robin Winter, Hatice Gokcan, et al. A community effort in SARS-CoV-2 drug discovery. Molecular informatics. 2024. 43. 1. e202300262
  • Kundan Solanki, Sajjan Rajpoot, Ashutosh Kumar, Kam Y J Zhang, Tomokazu Ohishi, Nik Hirani, Khandu Wadhonkar, Pramod Patidar, Qiuwei Pan, Mirza S Baig. Structural analysis of spike proteins from SARS-CoV-2 variants of concern highlighting their functional alterations. Future virology. 2022
  • Almasul Alfi, Aleksandr Popov, Ashutosh Kumar, Kam Y. J. Zhang, Svetlana Dubiley, Konstantin Severinov, Shunsuke Tagami. Cell-Free Mutant Analysis Combined with Structure Prediction of a Lasso Peptide Biosynthetic Protease B2. ACS Synthetic Biology. 2022
  • Wei Chen, Qi Chen, Ashutosh Kumar, Xi Jiang, Kam Y J Zhang, Qing Yang. Structure-based virtual screening of highly potent inhibitors of the nematode chitinase CeCht1. Journal of enzyme inhibition and medicinal chemistry. 2021. 36. 1. 1198-1204
  • Parismita Kalita, Aditya K. Padhi, Kam Y.J. Zhang, Timir Tripathi. Corrigendum to “Design of a peptide-based subunit vaccine against novel coronavirus SARS-CoV-2” [Microbial Pathog. 145 (2020) 104236](S0882401020305234)(10.1016/j.micpath.2020.104236). Microbial Pathogenesis. 2021. 160
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MISC (1件):
  • Suryavathi Viswanadhapalli, Kalarickal V. Dileep, Kam Y.J. Zhang, Hareesh B. Nair, Ratna K. Vadlamudi. Targeting LIF/LIFR signaling in cancer. Genes and Diseases. 2021
学歴 (3件):
  • 1986 - 1989 University of York Physics PhD
  • 1982 - 1984 Peking University Chemistry Master of Science
  • 1978 - 1982 Peking University Chemistry Bachelor of Science
経歴 (6件):
  • 2018/04 - 現在 RIKEN, Kanagawa, Japan. Center for Biosystems Dynamics Research Team Leader
  • 2013/04 - 2018/03 RIKEN, Kanagawa, Japan. Center for Life Science Technologies Team Leader
  • 2009/01 - 2013/03 RIKEN, Saitama, Japan. Advanced Science Institute Unit Leader
  • 2002/04 - 2008/12 Plexxikon, Inc., Berkeley, California, USA. Structural Biology Director of Structural Biology
  • 1994/11 - 2001/06 Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. Division of Basic Sciences Assistant Member
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