研究者
J-GLOBAL ID:202101013795767647   更新日: 2024年06月22日

小野木 康弘

Onogi Yasuhiro
所属機関・部署:
職名: 特命助教
研究分野 (1件): 代謝、内分泌学
研究キーワード (4件): Adipocytes ,  Obesity ,  Macrophage ,  Pericytes
競争的資金等の研究課題 (3件):
  • 2020 - 2022 マウス褐色脂肪組織の熱産生におけるP2X5受容体の役割
  • 2017 - 2019 肥満進展においてペリサイト局在の動的変化により形成される脂肪幹細胞ニッチの同定
  • 2012 - 2015 脂肪組織の肥大化と糖エネルギー代謝異常におけるPDGFシグナルの意義の解明
論文 (14件):
  • Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki, Toshiyasu Sasaoka. Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity. Molecular Medicine. 2024. 30. 1
  • Tsutomu Wada, Yuichiro Miyazawa, Misa Ikurumi, Kento Fuse, Akira Okekawa, Yasuhiro Onogi, Shigeru Saito, Hiroshi Tsuneki, Toshiyasu Sasaoka. A transdermal treatment with MC903 ameliorates diet-induced obesity by reducing visceral fat and increasing myofiber thickness and energy consumption in mice. Nutrition & Metabolism. 2023. 20. 1
  • Hiroshi Tsuneki, Takahiro Maeda, Shinjiro Takata, Masanori Sugiyama, Koyuki Otsuka, Hinako Ishizuka, Yasuhiro Onogi, Emi Tokai, Chiaki Koshida, Kanta Kon, et al. Hypothalamic orexin prevents non-alcoholic steatohepatitis and hepatocellular carcinoma in obesity. Cell Reports. 2022. 41. 3. 111497-111497
  • Elena López-Gonzales, Lisa Lehmann, Francisco Javier Ruiz Ojeda, René Hernández-Bautista, Irem Altun, Yasuhiro Onogi, Ahmed Elagamy Khalil, xue liu, Andreas Israel, Siegfried Ussar. L-Serine Supplementation Blunts Fasting-Induced Weight Regain by Increasing Brown Fat Thermogenesis. Nutrients. 2022. 14. 9. 1922-1922
  • Jiefu Wang, Yasuhiro Onogi, Martin Krueger, Josef Oeckl, Ruth Karlina, Inderjeet Singh, Stefanie M. Hauck, Regina Feederle, Yongguo Li, Siegfried Ussar. PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes. Molecular Metabolism. 2022. 101508-101508
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MISC (15件):
  • Yasuhiro Onogi, Siegfried Ussar. Regulatory networks determining substrate utilization in brown adipocytes. Trends in Endocrinology & Metabolism. 2022
  • Yasuhiro Onogi, Siegfried Ussar. Is epiploic fat the dermal fat of the intestine?. Gut. 2021. gutjnl-2021
  • Yasuhiro Onogi, Ahmed Elagamy Mohamed Mahmoud Khalil, Siegfried Ussar. Identification and characterization of adipose surface epitopes. Biochemical Journal. 2020. 477. 13. 2509-2541
  • Watanabe Eri, Wada Tsutomu, Onogi Yasuhiro, Tsuneki Hiroshi, Sasaoka Toshiyasu. Anagliptin, a DPP-4 Inhibitor, Attenuates Diet-Induced Obesity by Modulating Adipose Tissue Angiogenesis in Mice. DIABETES. 2017. 66. A541-A541
  • 和田 努, 小野木 康弘, 松澤 崇俊, 山本 誠士, 石井 陽子, 笹原 正清, 恒枝 宏史, 笹岡 利安. 脂肪組織の肥大化における脂肪血管ペリサイトの局在変化の意義. 日本内分泌学会雑誌. 2017. 93. 1. 268-268
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講演・口頭発表等 (4件):
  • Impact of SDF1/CXCR4 signaling on pericyte mobilization during obesity development.
    (The 17th Japan-Korea Diabetic Nephropathy Seminar)
  • Pro-inflammatory macrophages promote vascular remodeling in white adipose tissue during diet-induced obesity.
    (The 17th Japan-Korea Diabetic Nephropathy Seminar)
  • A novel mechanism of adipose-tissue angiogenesis via PDGF-B signaling in fat tissue expansion during obesity.
    (International Symposium of Korea University College of Medicine BK21 Plus Graduate Program)
  • Glycolytic activation promotes PDGF-B production in adipose tissue macrophages during obesity development.
    (American Diabetes Association 78th Scientific Sessions)
学歴 (1件):
  • 2013 - 2017 富山大学大学院 医学薬学教育部(薬学系) 博士後期課程
学位 (1件):
  • 博士(薬科学) (富山大学)
経歴 (3件):
  • 2022/08 - 現在 富山大学 学術研究部 教育研究推進系 特命助教
  • 2019/04 - 2022/08 Institute for Diabetes and Obesity, Helmholtz Center Munich RG Adipocytes and Metabolism Postdoctoral Fellow
  • 2017/04 - 2019/03 富山大学大学院 医学薬学研究部(薬学系) 病態制御薬理学 博士研究員
受賞 (9件):
  • 2020/06 - The Alexander von Humboldt Foundation Postdoctoral Research Fellowship
  • 2019/04 - 上原記念生命科学財団 海外留学助成金ポストドクトラルフェローシップ
  • 2017/05 - The 60th annual meeting of the Japan Diabetes Society Young Investigator Award
  • 2016/12 - The 28th annual meeting of the study group of Molecular Diabetology in Japan Young Investigator Award and Research Travel Grant
  • 2015/12 - The 27th annual meeting of the study group of Molecular Diabetology in Japan Research Travel Grant
全件表示
所属学会 (2件):
日本バイオインフォマティクス学会 ,  日本糖尿病学会
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