町谷充洋

マチタニミツヒロ | Machitani Mitsuhiro

所属機関・部署：
職名：ユニット長

研究分野 (3件)：ウイルス学 , 腫瘍生物学 , 分子生物学

競争的資金等の研究課題 (3件)：

論文 (24件)：

Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, et al. Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity. Nature cell biology. 2024
Mitsuhiro Machitani, Junko Takei, Mika K Kaneko, Saori Ueki, Hirofumi Ohashi, Koichi Watashi, Yukinari Kato, Kenkichi Masutomi. Development of novel monoclonal antibodies against nsp12 of SARS-CoV-2. Virology journal. 2022. 19. 1. 213-213
Yoko Matsuda, Taro Yamashita, Juanjuan Ye, Mami Yasukawa, Keiko Yamakawa, Yuri Mukai, Mitsuhiro Machitani, Yataro Daigo, Yohei Miyagi, Tomoyuki Yokose, et al. Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs. The Journal of pathology. 2022. 257. 2. 172-185
Mitsuhiro Machitani, Ichiro Taniguchi, Asako McCloskey, Tatsuya Suzuki, Mutsuhito Ohno. The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response. RNA (New York, N.Y.). 2020. 26. 11. 1716-1725
Mitsuhiro Machitani, Mami Yasukawa, Jotaro Nakashima, Yasuhiro Furuichi, Kenkichi Masutomi. RNA-dependent RNA polymerase, RdRP, a promising therapeutic target for cancer and potentially COVID-19. Cancer science. 2020. 111. 11. 3976-3984

MISC (4件)：

K. Wakabayashi, M. Machitani, M. Tachibana, F. Sakurai, H. Mizuguchi. Small RNA derived from Adenovirus Virus-Associated RNA II, mivaRNA II, promotes Ad replication via post-transcriptional gene silencing. HUMAN GENE THERAPY. 2016. 27. 11. A174-A174
K. Tomita, F. Sakurai, M. Machitani, M. Tachibana, H. Mizuguchi. Effects of antibodies against adenoviral capsid proteins on adenovirus vector-mediated in vivo transduction. HUMAN GENE THERAPY. 2016. 27. 11. A148-A148
Mitsuhiro Machitani, Kazufumi Katayama, Fuminori Sakurai, Hayato Matsui, Tomoko Yamaguchi, Takayuki Suzuki, Hiroyuki Miyoshi, Kenji Kawabata, Hiroyuki Mizuguchi. DEVELOPMENT OF AN ADENOVIRUS VECTOR LACKING THE VIRUS-ASSOCIATED RNA EXPRESSION. JOURNAL OF GENE MEDICINE. 2014. 16. 7-8. 234-235
Mitsuhiro Machitani, Fuminori Sakurai, Keisaku Wakabayashi, Masashi Tachibana, Hiroyuki Mizuguchi. Evaluation of Involvement of microRNA Processing Factors in Adenovirus Replication. MOLECULAR THERAPY. 2014. 22. S32-S32

書籍 (1件)：

講演・口頭発表等 (6件)：

がん細胞におけるhTERTのRdRP活性とR-loop制御
(大阪大学微生物病研究所セミナー 2024)
hTERTのRNA依存性RNAポリメラーゼ活性によるR-loop制御機構
(がん研究会がん研セミナー 2024)
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity
(第83回日本癌学会学術総会 2024)
Maintenance of genome integrity by RNA-dependent RNA polymerase activity of hTERT
(第46回日本分子生物学会年会 2023)
アデノウイルス由来小分子RNAの機能特性に立脚した遺伝子治療用組換えウイルスの開発
(第66回日本薬学会近畿支部総会 2016)

学位 (1件)：

経歴 (5件)：

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町谷 充洋