2024 - 2025 AI 支援と構造解析を融合したスイッチ型抗体薬物複合体の超高速スクリーニング法の創成
論文 (8件):
Masahiko Taguchi, Shun Sakuraba, Justin Chan, Hidetoshi Kono. Unveiling the Photoactivation Mechanism of BLUF Photoreceptor Protein through Hybrid Quantum Mechanics/Molecular Mechanics Free-Energy Calculation. ACS Physical Chemistry Au. 2024. 4. 6. 647-659
Masahiko Taguchi, Ryo Oyama, Masahiro Kaneso, Shigehiko Hayashi. Hybrid QM/MM Free-Energy Evaluation of Drug-Resistant Mutational Effect on the Binding of an Inhibitor Indinavir to HIV-1 Protease. Journal of Chemical Information and Modeling. 2022. 62. 5. 1328-1344
Effi Haque, Aamir Salam Teeli, Dawid Winiarczyk, Masahiko Taguchi, Shun Sakuraba, Hidetoshi Kono, Paweł Leszczyński, Mariusz Pierzchała, Hiroaki Taniguchi. HNF1A POU Domain Mutations Found in Japanese Liver Cancer Patients Cause Downregulation of HNF4A Promoter Activity with Possible Disruption in Transcription Networks. Genes. 2022. 13. 3. 413
Amarjeet Kumar, Justin Chan, Masahiko Taguchi, Hidetoshi Kono. Interplay among transacting factors around promoter in the initial phases of transcription. Current Opinion in Structural Biology. 2021. 71. 7-15
Aleksandr E. Svetogorov, Masahiko Taguchi, Yasuhiro Tokura, Denis M. Basko, Frank W. J. Hekking. Theory of coherent quantum phase slips in Josephson junction chains with periodic spatial modulations. Physical Review B. 2018. 97. 10