研究者
J-GLOBAL ID:202301016710211380   更新日: 2024年04月10日

関水 和久

セキミズ カズヒサ | Sekimizu Kazuhisa
所属機関・部署:
職名: 教授
研究キーワード (1件): カイコ創薬
競争的資金等の研究課題 (42件):
  • 2021 - 2024 食品由来の強力な自然免疫活性化能を示す新規物質の作用機序解析
  • 2017 - 2020 宿主環境下での病原性に寄与するncRNAの網羅的解析
  • 2015 - 2020 治療効果を指向した新規抗菌薬の創出
  • 2014 - 2017 糖尿病宿主内での細菌の適応機構の包括的な理解
  • 2013 - 2015 治療効果を指標に同定された新規抗菌薬の作用機序解析
全件表示
論文 (32件):
  • Junhao Fu, Yosuke Nakata, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Molecular Editing Enhances Oxidation Resistance of Mena-quinone-Targeting Antibiotics Lysocin E and WAP-8294A2. Chemistry - A European Journal. 2023
  • Yosuke Nakata, Junhao Fu, Hiroaki Itoh, Suresh Panthee, Hiroshi Hamamoto, Kazuhisa Sekimizu, Masayuki Inoue. Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives. Chemistry (Weinheim an der Bergstrasse, Germany). 2023. e202301225
  • Atsushi Miyashita, Keiko Kataoka, Toshio Tsuchida, Akihiko Ano Ogasawara, Hiroto Nakajima, Megumu Takahashi, Kazuhisa Sekimizu. High molecular weight glucose homopolymer of broccoli (Brassica oleracea var. italica) stimulates both invertebrate and mammalian immune systems. Frontiers in Food Science and Technology. 2023. 3
  • 浜本 洋, Panthee Suresh, Paudel Atmika, 宮下 惇嗣, 関水 和久. 選抜ワークショップ5:抗菌性物質、薬剤耐性 新規抗生物質ライソシンEは宿主と微生物の相互作用を利用して高い治療効果を発揮する. 日本細菌学雑誌. 2022. 77. 1. 57-57
  • Atsushi Miyashita, Shuhei Mitsutomi, Tohru Mizushima, Kazuhisa Sekimizu. Repurposing the PDMA-approved drugs in Japan using an insect model of staphylococcal infection. FEMS microbes. 2022. 3. xtac014
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MISC (144件):
  • 宮下惇嗣, 斎藤優, 藤本ゆかり, 新家一男, 関水和久. 微生物病原体に対する自然免疫. 日本細菌学雑誌(Web). 2023. 78. 1
  • 関水和久, 宮下惇嗣, LI Wenyuan, 三上雄大, YU Yidong, 浜本洋. カイコを用いた敗血症性DIC(播種性血管内凝固症候群)モデルの構築. 日本薬学会年会要旨集(Web). 2023. 143rd
  • Hiroshi Hamamoto, Atsushi Miyashita, Koushirou Kamura, Ryo Horie, Kazuhisa Sekimizu. Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret. Drug discoveries & therapeutics. 2022. 16. 6. 280-285
  • Atsushi Miyashita, Kazuhisa Sekimizu, Chikara Kaito. Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus). Drug discoveries & therapeutics. 2022. 16. 5. 204-209
  • Suresh Panthee, Hiroshi Hamamoto, Atmika Paudel, Chikara Kaito, Yutaka Suzuki, Kazuhisa Sekimizu. Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220. Heliyon. 2022. 8. 11. e11376
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講演・口頭発表等 (100件):
  • Silkworm arylsulfatase in the midgut content is expressed in the silk gland and fed via smearing on the food from the spinneret.
    (Drug discoveries & therapeutics 2022)
  • Surrounding gas composition affects the calling song development in the two-spotted cricket (Gryllus bimaculatus).
    (Drug discoveries & therapeutics 2022)
  • Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.
    (Heliyon 2022)
  • Lysocin E Targeting Menaquinone in the Membrane of Mycobacterium tuberculosis Is a Promising Lead Compound for Antituberculosis Drugs.
    (Antimicrobial agents and chemotherapy 2022)
  • Transcriptome change of Staphylococcus aureus in infected mouse liver.
    (Communications biology 2022)
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