菊地晴久

キクチハルヒサ | Kikuchi Haruhisa

所属機関・部署：
職名：教授
ホームページURL (2件)： http://www.pha.keio.ac.jp/research/nm/index.html , http://www.pha.keio.ac.jp/en/research/index.html

研究分野 (3件)：環境、天然医薬資源学 , 薬系化学、創薬科学 , 生物分子化学

研究キーワード (3件)：多様性指向型合成 , 生物活性物質 , 天然化合物

競争的資金等の研究課題 (32件)：

全件表示

論文 (131件)：

Ryusei Araya, Shihu Men, Yoshinori Uekusa, Zaiqiang Yu, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shogo Kawaguchi, Ken-Ichi Furukawa, Yoshiteru Oshima, et al. The inhibitory effect of DIF-3 on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells. Journal of pharmacological sciences. 2024. 154. 3. 157-165
Yuzuru Kubohara, Yuko Fukunaga, Ayako Shigenaga, Haruhisa Kikuchi. Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake via Direct Inhibition of Mitochondrial Malate Dehydrogenase in Mouse 3T3-L1 Cells. International Journal of Molecular Sciences. 2024. 25. 3. 1889-1889
Yuzuru Kubohara, Yuko Fukunaga, Haruhisa Kikuchi, Hidekazu Kuwayama. Pharmacological Evidence That Dictyostelium Differentiation-Inducing Factor 1 Promotes Glucose Uptake Partly via an Increase in Intracellular cAMP Content in Mouse 3T3-L1 Cells. Molecules. 2023. 28. 23. 7926-7926
Hidekazu Kuwayama, Haruhisa Kikuchi, Yuzuru Kubohara. Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum. Biology. 2023. 12. 6. 873-873
AIRI HIRAYAMA, HIROTAKA ISHIGAKI, KATSUNORI TAKAHASHI, YUSUKE MIURA, HARUHISA KIKUCHI, YUZURU KUBOHARA. <i>Dictyostelium</i> Differentiation-inducing Factor Derivatives Reduce the Glycosylation of PD-L1 in MDA-MB-231 Human Breast Cancer Cells. Juntendo Medical Journal. 2023

MISC (13件)：

Liu Xu, Zaiqiang Yu, Yoshinori Uekusa, Shogo Kawaguchi, Haruhisa Kikuchi, Kazuyuki Daitoku, Masahito Minakawa, Shigeru Motomura, Ken-Ichi Furukawa, Yoshiteru Oshima, et al. Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinicepolycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells(vol 149, pg 147, 2022). JOURNAL OF PHARMACOLOGICAL SCIENCES. 2023. 151. 1. 63-64
Gaowa Bai, Toshiro Niki, Haruhisa Kikuchi, Ayako Sumi, Nobuyuki Kobayashi, Takahiro Haruyama, Jing Zhang, Haorile Chagan-Yasutan, Toshio Hattori. New Development of Disaster-Related and Tropical Infectious Diseases Control. Reports - Medical Cases, Images, and Videos. 2020. 3. 1. 5-5
久保原禅, 菊地晴久, 大島吉輝. Derivatives of Dictyostelium differentiation-inducing factors inhibit serum-dependent cell migration of murine osteosarcoma LM8 cells. Juntendo Medical Journal. 2018
Y.Ando, K. Ota, I. Ito, H. Kikuchi, Y. Oshima, Y. Endo, K. Uwai, K. Tokuraku. Screening of amyloid-β aggregation inhibitors from aromatic low molecular compounds by a microliter-scale high-throughput screening system with quantam-dot nanoprobes. Neuroscience 2017. 2017
Yuichi Ando, Kiminori Ota, Ikuko Ito, Haruhisa Kikuchi, Yoshiteru Oshima, Yasuyuki Endo, Koji Uwai, Kiyotaka Tokuraku. Discovery of lead compounds targeting Amyloid-β aggregation from aromatic low-molecular compounds. Joint Seminar on Environmental Science and Disaster Mitigation Research 2017. 2017. 83-84

特許 (24件)：

書籍 (1件)：

講演・口頭発表等 (23件)：

天然物創薬研究における細胞性粘菌
(第13回日本細胞性粘菌学会 2023)
Research results on anti-trypanosomal natural compounds at Keio University in the context of SATREPS-CHAGAS project
(Presentation of results of the Project for Integrated Research and Development towards Chagas Disease Control 2023)
天然資源探索と多様性指向型合成の複合による構造多様化合物群創製法の開発
(日本生薬学会第68年会 2022)
Development of Natural Product-Like Compound Library Based on Diversity-Enhanced Extracts
(The 5th Japan-Taiwan Joint Symposium for Pharmaceutical Sciences 2019)
創薬シーズを指向した天然物を越える構造多様化合物群の創出
(BINDS: ケミカルシーズ・リード探索ユニットジョイントシンポジウム 2019 IN 仙台 2019)

学歴 (2件)：

学位 (1件)：

経歴 (5件)：

委員歴 (6件)：

全件表示

受賞 (5件)：

所属学会 (4件)：

日本細胞性粘菌学会 , 日本生薬学会 , 有機合成化学協会 , 日本薬学会

※　J-GLOBALの研究者情報は、researchmapの登録情報に基づき表示しています。登録・更新については、こちらをご覧ください。

菊地 晴久