野原 恵子

• 筑波大学  生命環境科学研究科   教授

• 環境化学物質のエピジェネティクス作用
• ダイオキシンの免疫毒性
• Epigenetics of environmental chemicals
• Immunotoxicity of TCDD

• Shota Takumi, Yasunobu Aoki, Tornoharu Sano, Takehiro Suzuki, Takehiko Nohmi, Keiko Nohara. In vivo mutagenicity of arsenite in the livers of gpt delta transgenic mice. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS. 2014. 760. 42-47
• Takehiro Suzuki, Satoshi Yamashita, Toshikazu Ushijima, Shota Takumi, Tomoharu Sano, Takehiro Michikawa, Keiko Nohara. Genome-wide analysis of DNA methylation changes induced by gestational arsenic exposure in liver tumors. CANCER SCIENCE. 2013. 104. 12. 1575-1585
• Keiko Nohara, Yukiyo Tateishi, Takehiro Suzuki, Kazuyuki Okamura, Hikari Murai, Shota Takumi, Fumihiko Maekawa, Noriko Nishimura, Masuko Kobori, Takaaki Ito. Late-onset Increases in Oxidative Stress and Other Tumorigenic Activities and Tumors With a Ha-ras Mutation in the Liver of Adult Male C3H Mice Gestationally Exposed to Arsenic. TOXICOLOGICAL SCIENCES. 2012. 129. 2. 293-304
• Taisuke Nakahama, Akihiro Kimura, Nam Trung Nguyen, Ichino Chinen, Hamza Hanieh, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto. Aryl hydrocarbon receptor deficiency in T cells suppresses the development of collagen-induced arthritis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011. 108. 34. 14222-14227
• Keiko Nohara, Takashi Baba, Hikari Murai, Yayoi Kobayashi, Takehiro Suzuki, Yukiyo Tateishi, Michiyo Matsumoto, Noriko Nishimura, Tomoharu Sano. Global DNA methylation in the mouse liver is affected by methyl deficiency and arsenic in a sex-dependent manner. ARCHIVES OF TOXICOLOGY. 2011. 85. 6. 653-661

• Akihiro Kimura, Tetsuji Naka, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008. 105. 28. 9721-9726
• Akihiro Kimura, Tetsuji Naka, Keiko Nohara, Yoshiaki Fujii-Kuriyama, Tadamitsu Kishimoto. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008. 105. 28. 9721-9726
• Keiko Nohara, Kana Ao, Yoshimi Miyamoto, Takehiro Suzuki, Satoru Imaizumi, Yukiyo Tateishi, Seiichi Omura, Chiharu Tohyama, Takahiro Kobayashi. Arsenite-induced thymus atrophy is mediated by cell cycle arrest: A characteristic downregulation of E2F-Related genes revealed by a microarray approach. TOXICOLOGICAL SCIENCES. 2008. 101. 2. 226-238
• Keiko Nohara, Kana Ao, Yoshimi Miyamoto, Takehiro Suzuki, Satoru Imaizumi, Yukiyo Tateishi, Seiichi Omura, Chiharu Tohyama, Takahiro Kobayashi. Arsenite-induced thymus atrophy is mediated by cell cycle arrest: A characteristic downregulation of E2F-Related genes revealed by a microarray approach. TOXICOLOGICAL SCIENCES. 2008. 101. 2. 226-238
• Takehiro Suzuki, Keiko Nohara. Regulatory factors involved in species-specific modulation of arylhydrocarbon receptor (AhR)-dependent gene expression in humans and mice. JOURNAL OF BIOCHEMISTRY. 2007. 142. 4. 443-452

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• Doctor of Philosophy

• 2013/10 - 現在 食品安全委員会 専門委員
• - 現在 日本免疫毒性学会 理事、評議員
• - 現在 日本衛生学会 評議員、編集委員
• 2007 - 2008 Society of Toxicology (USA) Member of the Program Committee of Immunotoxicology Specialty Section
• 2007 - 2008 Society of Toxicology (USA) Member of the Program Committee of Immunotoxicology Specialty Section
The Japanese Society of Immunotoxicology councilor

日本衛生学会 ,  日本免疫学会 ,  日本分子生物学会 ,  Society of Toxicology (USA) ,  日本免疫毒性学会 ,  The Japanese Biochemical Society ,  The Japanese Society for Immunology ,  The Molecular Biology Society of Japan ,  Society of Toxicology (USA) ,  The Japanese Society of Immunotoxicology