西道隆臣

(1)脳内におけるbetaアミロイド分解システムの解析 (2)ヒト脳老化動物モデルの作成 (3)脳老化に伴う病理変化における細胞内プロテアーゼの役割の解析
(1) Analysis of in vivo catabolism of A beta peptide in brain (2) Production of animal models producing the pathological form of Abeta, Abeta3(pE)-40/42 (3) Roles of cytoplasmic proteases in aging-associated neuropathology

Keiro Shirotani, Satoshi Tsubuki, Nobuhisa Iwata, Yoshie Takaki, Wakako Harigaya, Kei Maruyama, Sumiko Kiryu-Seo, Hiroshi Kiyama, Hiroshi Iwata, Taisuke Tomita, et al. Neprilysin Degrades Both Amyloid β Peptides 1-40 and 1-42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases. Journal of Biological Chemistry. 2001. 276. 24. 21895-21901
Keiro Shirotani, Satoshi Tsubuki, Nobuhisa Iwata, Yoshie Takaki, Wakako Harigaya, Kei Maruyama, Sumiko Kiryu-Seo, Hiroshi Kiyama, Hiroshi Iwata, Taisuke Tomita, et al. Neprilysin Degrades Both Amyloid β Peptides 1-40 and 1-42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases. Journal of Biological Chemistry. 2001. 276. 24. 21895-21901
N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N. P. Gerard, C. Gerard, E. Hama, H. J. Lee, T. C. Saido. Metabolic regulation of brain Aβ by neprilysin. Science. 2001. 292. 5521. 1550-1552
N. Iwata, S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N. P. Gerard, C. Gerard, E. Hama, H. J. Lee, T. C. Saido. Metabolic regulation of brain Aβ by neprilysin. Science. 2001. 292. 5521. 1550-1552
Hahn-Jun Lee, Masanori Tomioka, Yoshie Takaki, Hajime Masumoto, Takaomi C. Saido. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Biochimica et Biophysica Acta - Gene Structure and Expression. 2000. 1493. 1-2. 273-278

アルツハイマー病の危険因子または防止因子のスクリーニング法

筑波大学第2学群生物学類
東京大学大学院薬学系研究科
筑波大学
University of Tokyo Graduate School

薬学博士

1997 - 現在 Visiting Professor, Tohoku University School of
1997 - 現在 Visiting Professor, Yokohama City Medical
1997 - 現在 Laboratory Head, RIKEN Brain Science Institute
1999 - 筑波大学医学部非常勤講師(兼任)継続中
1999 - Visiting Professor, University of Tsukuba School of

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1995 日本生化学会奨励賞
1985 国際ロータリー財団大学院留学フェローシップ
1995 Young Investigator Award, Japanese Biochemical Society
1985 Rotary International Fellowship

病態と治療におけるプロテアーゼとインヒビター研究会 , 日本薬学会 , 日本痴呆学会 , 日本生化学会 , 日本神経科学会 , 日本神経化学会 , The Pharmaceutical Society of Japan , The Japanese Society for Neurochemistry , The Japanese Biochemical Society , Society for proteases and protease inhibitors in diseases and therapies , Japanese Society for Dementia Research , Japan Neuroscience Society

西道 隆臣