小林博也

コバヤシヒロヤ | Kobayashi Hiroya

研究分野 (3件)：免疫学 , 実験病理学 , 人体病理学

競争的資金等の研究課題 (3件)：

2023 - 2026 頭頸部癌特異的T細胞を活用した複合型免疫療法の開発
HLA分子による免疫制御機構の研究
Study on mechauism of immunoregulation by HLA moleles

論文 (16件)：

Akemi Kosaka, Kei Ishibashi, Toshihiro Nagato, Hidemitsu Kitamura, Yukio Fujiwara, Syunsuke Yasuda, Marino Nagata, Shohei Harabuchi, Ryusuke Hayashi, Yuki Yajima, et al. CD47 blockade enhances the efficacy of intratumoral STING-targeting therapy by activating phagocytes. Journal of Experimental Medicine. 2021. 218. 11
Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, et al. A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy. Cancer science. 2021. 112. 7. 2705-2713
Michihisa Kono, Takumi Kumai, Ryusuke Hayashi, Hidekiyo Yamaki, Hiroki Komatsuda, Risa Wakisaka, Toshihiro Nagato, Takayuki Ohkuri, Akemi Kosaka, Kenzo Ohara, et al. Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery. Cancer immunology, immunotherapy : CII. 2021
Ryusuke Hayashi, Toshihiro Nagato, Takumi Kumai, Kenzo Ohara, Mizuho Ohara, Takayuki Ohkuri, Yui Hirata-Nozaki, Shohei Harabuchi, Akemi Kosaka, Marino Nagata, et al. Expression of placenta-specific 1 and its potential for eliciting anti-tumor helper T-cell responses in head and neck squamous cell carcinoma. Oncoimmunology. 2020. 10. 1. 1856545-1856545
Shohei Harabuchi, Akemi Kosaka, Yuki Yajima, Marino Nagata, Ryusuke Hayashi, Takumi Kumai, Kenzo Ohara, Toshihiro Nagato, Kensuke Oikawa, Mizuho Ohara, et al. Intratumoral STING activations overcome negative impact of cisplatin on antitumor immunity by inflaming tumor microenvironment in squamous cell carcinoma. Biochemical and biophysical research communications. 2020. 522. 2. 408-414

MISC (7件)：

Hiroya Kobayashi, Toshihiro Nagato, Keisuke Sato, Naoko Aoki, Shoji Kimura, Masamoto Murakami, Hajime Iizuka, Makoto Azumi, Hidehiro Kakizaki, Masatoshi Tateno, et al. Recognition of prostate and melanoma tumor cells by six-transmembrane epithelial antigen of prostate-specific helper T lymphocytes in a human leukocyte antigen class II-restricted manner. CANCER RESEARCH. 2007. 67. 11. 5498-5504
H Kobayashi, T Kokubo, K Abe, K Sato, S Kimura, N Miyokawa, M Katagiri. Analysis of anchor residues in a naturally processed HCA-DR53 ligand. IMMUNOGENETICS. 1996. 44. 5. 366-371
H TAKAHASHI, H KOBAYASHI, Y HASHIMOTO, S MATSUO, H IIZUKA. INTERFERON-GAMMA-DEPENDENT STIMULATION OF FAS ANTIGEN IN SV40-TRANSFORMED HUMAN KERATINOCYTES - MODULATION OF THE APOPTOTIC PROCESS BY PROTEIN-KINASE-C. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1995. 105. 6. 810-815
H TAKAHASHI, H KOBAYASHI, S MATSUO, H IIZUKA. REPRESSION OF INVOLUCRIN GENE-EXPRESSION BY TRANSCRIPTIONAL ENHANCER FACTOR 1 (TEF-1). ARCHIVES OF DERMATOLOGICAL RESEARCH. 1995. 287. 8. 740-746
H KOBAYASHI, K SATO, N MIYOKAWA, S KIMURA, M NAKASHIMA, M KATAGIRI. ANALYSIS OF NATURALLY PROCESSED HUMAN HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN CLASS I-BOUND PEPTIDES FROM HEPATOCELLULAR-CARCINOMA TISSUES IN-VIVO. JAPANESE JOURNAL OF CANCER RESEARCH. 1995. 86. 10. 962-968

学歴 (4件)：

- 1995 旭川医科大学医学研究科医学
- 1995 旭川医科大学
- 1991 旭川医科大学医学部
- 1991 旭川医科大学

学位 (1件)：

博士(医学)

所属学会 (3件)：

日本病理学会 , 日本癌学会 , 日本免疫学会

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小林 博也

小林博也