山口陽子

ヤマグチヨウコ | Yamaguchi Yoko

所属機関・部署：
職名：客員教授
ホームページURL (1件)： http://www.cityofhope.org/people/fujita-yamaguchi-yoko

研究分野 (2件)：機能生物化学 , 構造生物化学

研究キーワード (5件)：放線菌由来のレクチンSHAの復活研究 , 糖鎖特異的単鎖抗体の発現・解析 , IGF-I recptor signaling , がん分子標的治療法 , Molecular targeted-strategy utilizing antibodies against carbohydrates and IGF-I receptor

競争的資金等の研究課題 (6件)：

2010 - 2012 新規糖鎖特異的単鎖抗体の大腸菌発現系による大量発現と糖鎖結合性解析
2003 - 2009 Production of single chain antibodies (scFvs) against a variety of carbohydrate epitopes
2003 - 2008 研究領域「糖鎖の生物機能の解明と利用技術」研究課題「糖鎖構造特異的単鎖抗体ライブラリーの構築」
2005 - 2007 インスリン様増殖因子(IGF)-I 受容体とがん分子標的治療法
2005 - 2007 Single chain antibodies against IGF-(]G0001[) receptor as potential therapeutics for cancer

全件表示

論文 (24件)：

Yoko Fujita-Yamaguchi, Hideyuki Muramatsu, Alonso Tapia, Karine Bagramyan, Moksha Desai, Yasuhiro Takehana, Masayuki Igarashi, Yoshiki Yamaguchi, Markus Kalkum. Proteolytic Processing, Maturation, and Unique Synteny of the Streptomyces Hemagglutinin SHA. Microbiology spectrum. 2021. 9. 2. e0076621
Naoki Takizawa, Yoshitoshi Ogura, Yoko Fujita, Takeshi Noda, Hideki Shigematsu, Tetsuya Hayashi, Ken Kurokawa. Local structural changes of the influenza A virus ribonucleoprotein complex by single mutations in the specific residues involved in efficient genome packaging. Virology. 2019. 531. 126-140
Fujita-Yamaguchi Y, Bagramyan K, Yamaguchi Y, Ikeda A, Dohmae N, Hong TB, Kalkum M. Mass spectrometric revival of an l-rhamnose- and d-galactose-specific lectin from a lost strain of Streptomyces. The Journal of biological chemistry. 2018. 293. 1. 368-378
Nakata M, Kawaguchi S, Oikawa A, Inamura A, Nomoto S, Miyai H, Nonaka T, Ichimi S, Fujita-Yamaguchi Y, Luo C, et al. An aqueous extract from toad skin prevents gelatinase activities derived from fetal serum albumin and serum-free culture medium of human breast carcinoma MDA-MB-231 cells. Drug discoveries & therapeutics. 2016. 9. 6. 417-421
Hirose-Yotsuya L, Okamoto F, Yamakawa T, Whitson RH, Fujita-Yamaguchi Y, Itakura K. Knockdown of AT-rich interaction domain (ARID) 5B gene expression induced AMPKα2 activation in cardiac myocytes. Bioscience trends. 2015. 9. 6. 377-385

MISC (166件)：

Yoko Fujita-Yamaguchi, Yoshiki Yamaguchi, Akemi Ikeda, Naoshi Domae, Karine Bagramyan, Teresa B. Hong, John P. Murad, Markus Kalkum. Primary structure determination of a blood group B-specific lectin purified from Streptomyces sp 27S5 reveals insight into its mechanism of expression and unique structural features. GLYCOBIOLOGY. 2016. 26. 12. 1415-1415
Markus Kalkum, Teresa Hong, Karine Bagramyan, Yoko Fujita-Yamaguchi. Proteomics and Genomics Provide Novel Insights Into Streptomyces Lectin Biochemistry. GLYCOBIOLOGY. 2014. 24. 11. 1115-1116
Yoko Fujita-Yamaguchi, Astufumi Nakazawa, Noriyuki Yuasa. Expression and Purification of Anti-IGF-I Receptor 1H7 Constructs in Drosophila S2 Cells. ENDOCRINE REVIEWS. 2014. 35. 3
Hiroyuki Kato, Takahito Fukuda, Noriyuki Yuasa, Yoko Fujita-Yamaguchi. Expression, purification, and refolding of single chain antibodies (scFvs) from inclusion bodies. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012. 244
Tsubasa Koyama, Daisuke Takada, Yoshiki Yamaguchi, Noriyuki Yuasa, Ayano Matsumoto-Takasaki, Yoko Fujita-Yamaguchi. In vitro production of anticarbohydrate antibodies: Purification of anti-T antigen antibodies (scFvs) from E. coli inclusion bodies and Drosophila S2 cell culture media. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012. 244

書籍 (6件)：

Isolation and characterization of antibodies against three consecutive Tn-antigen clusters from a phage library displaying human single-chain variable fragments.
J. Biochem. (Sakai, K., Yuasa, N., Tsukamoto, K., Takasaki-Matsumoto, A., Yajima, Y., Sato, R., Kawakami, H., Mizuno, M., Takayanagi, A., Shimizu, N., Nakata, M., and Fujita-Yamaguchi, Y. ) 2010
Preparation of asialo-agalacto-glycophorin A for screening of anti-Tn antibodies.
Biosci. Trends. Koizumi, T., Matsumoto-Takasaki, A., Nakada, H., Nakata, M., Fujita-Yamaguchi, Y. 2010
Production of anti-carbohydrate antibodies by phage-display technologies: Potential impairment of cell growth as a result of endogenous expression.
J. Biol. Chem. (Yuasa, N., Zhang, W., Goto, T., Sakaue, H., Matsumoto- Takasaki, A., Kimura, M., Ohshima, H., Tsuchida, Y., Koizumi, T., Sakai, K., Kojima, T., Yamamoto, K., Nakata, M., and Fujita-Yamaguchi, Y.) 2010
Preparation of asialo-agalacto-glycophorin A for screening of anti-Tn antibodies.
Biosci. Trends. (Koizumi, T., Matsumoto-Takasaki, A., Nakada, H., Nakata, M., Fujita-Yamaguchi, Y.) 2010
Production of anti-carbohydrate antibodies by phage-display technologies: Potential impairment of cell growth as a result of endogenous expression.
J. Biol. Chem. (110) Yuasa, N., Zhang, W., Goto, T., Sakaue, H., Matsumoto- Takasaki, A., Kimura, M., Ohshima, H., Tsuchida, Y., Koizumi, T., Sakai, K., Kojima, T., Yamamoto, K., Nakata, M., and Fujita-Yamaguchi, Y.) 2010

学歴 (6件)：

- 1977 東京大学農学系研究科農芸化学
- 1977 東京大学
- 1973 東京大学農学系研究科農芸化学
- 1973 東京大学
- 1971 埼玉大学理工学部生化学

全件表示

学位 (1件)：

農学博士 (東京大学)

経歴 (8件)：

2022/05 - 現在順天堂大学大学院医学研究科客員教授
2014/04 - 現在 City of Hope ベックマン研究所 Diabetes & Metabolism Res. Inst. Professor Emeritus
2000 - 2014/03 東海大学工学部生命化学科教授 & 米国City of Hopeベックマン研究所Adjunct Professor of Molecular Biology
1981 - 2000 米国City of Hopeベックマン研究所Assistant ProfessorからProfessor of Molecular Biology
1981 - 2000 Assistant Professor to Professor of Molecular Biology at Beckman Research Institute of the City of Hope

全件表示

所属学会 (3件)：

アメリカ内分泌学会(The Endocrine Society) , 日本生化学学会 , アメリカ生化学・分子生物学会(American Society for Biochemistry and Molecular Biology)

※　J-GLOBALの研究者情報は、researchmapの登録情報に基づき表示しています。登録・更新については、こちらをご覧ください。

前のページに戻る

山口 陽子

山口陽子