伊藤貴浩

イトウタカヒロ | Ito Takahiro

研究分野 (5件)：腫瘍生物学 , 血液、腫瘍内科学 , 医化学 , 薬系衛生、生物化学 , 分子生物学

研究キーワード (5件)：代謝 , 幹細胞 , がん , 遺伝子発現制御 , 造血

競争的資金等の研究課題 (14件)：

2024 - 2027 疾病キラルバイオマーカー定量を指向した高感度・高精度なオンチップ分離分析法の開発
2024 - 2026 AI利用型高速画像解析による核小体動態の分子解剖
2021 - 2026 Mechanism and Regulation of Stem Cell Fates by the Branched-Chain Amino Acid Metabolism in Cancer
2021 - 2024 白血病単一細胞分岐鎖アミノ酸代謝特性解析のためのマイクロ分離分析法の開発
2019 - 2021 RNA結合タンパクMSI2の限定分解によるがん幹細胞の運命制御機構

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論文 (47件)：

Emily R Hildebrandt, Shaneela A Hussain, Michelle A Sieburg, Rajani Ravishankar, Nadeem Asad, Sangram Gore, Takahiro Ito, James L Hougland, Timothy M Dore, Walter K Schmidt. Targeted genetic and small molecule disruption of N-Ras CaaX cleavage alters its localization and oncogenic potential. Bioorganic chemistry. 2024. 147. 107316-107316
Ruochong Wang, Futaba Kato, Rio Yasui Watson, Aaron M Beedle, Jarrod A Call, Yugo Tsunoda, Takeshi Noda, Takaho Tsuchiya, Makoto Kashima, Ayuna Hattori, et al. The RNA-binding protein Msi2 regulates autophagy during myogenic differentiation. Life science alliance. 2024. 7. 5
Koji Jimbo, Ayuna Hattori, Shuhei Koide, Takahiro Ito, Katsuhiro Sasaki, Kazuhiro Iwai, Yasuhito Nannya, Atsushi Iwama, Arinobu Tojo, Takaaki Konuma. Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia. Leukemia. 2022. 37. 1. 122-133
Koji Jimbo, Yaeko Nakajima-Takagi, Takahiro Ito, Shuhei Koide, Yasuhito Nannya, Atsushi Iwama, Arinobu Tojo, Takaaki Konuma. Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation. Leukemia. 2022. 36. 6. 1550-1562
Takuma Ohtawa, Ayuna Hattori, Muneki Isokawa, Masashi Harada, Takashi Funatsu, Takahiro Ito, Makoto Tsunoda. Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography. Journal of Chromatography Open. 2021. 1. 100005-100005

MISC (6件)：

Koji Jimbo, Shuhei Koide, Takahiro Ito, Arinobu Tojo, Katsuhiro Sasaki, Kazuhiro Iwai, Atsushi Iwama, Yasuhito Nannya, Takaaki Konuma. Deficiency of the E3 Ligase Hoip Impairs Adult Hematopoiesis and Myeloid Leukemia. BLOOD. 2021. 138
Koji Jimbo, Takaaki Konuma, Takahiro Ito, Yaeko Nakajima-Takagi, Atsushi Iwama, Arinobu Tojo. Immunoglobulin Superfamily Member 8 Is Indispensable for Myeloid Leukemia Via Wnt/beta-Catenin Signaling Pathway. BLOOD. 2020. 136
Ayuna Hattori, Takahiro Ito. ROLE OF AMINO ACID METABOLISM IN CANCER PROGRESSION. EXPERIMENTAL HEMATOLOGY. 2016. 44. 9. S78-S78
Ayuna Hattori, Takahiro Ito. AMINO ACID METABOLISM IN MYELOID LEUKEMIA. EXPERIMENTAL HEMATOLOGY. 2015. 43. 9. S66-S66
S. Takiguchi, M. Yaguchi, K. Ogawa, Y. Wada, K. Matsusue, T. Ito, H. Hamamoto, N. Akimitsu, K. Sekimizu, Y. Toh, et al. Premature Aging-Like Phenotypes in Metastasis-Associated Protein I (Mta1) Null Mice. JOURNAL OF BONE AND MINERAL RESEARCH. 2008. 23. S129-S129

学歴 (3件)：

経歴 (8件)：

2022 - 現在京都大学医生物学研究所教授
2019 - 2022 京都大学ウイルス・再生医科学研究所教授
2019 - 2019 University of Georgia Dept of Biochemistry and Molecular Biology Associate Professor
2013 - 2019 University of Georgia Dept of Biochemistry and Molecular Biology Assistant Professor
2011 - 2013 University of California San Diego Dept of Pharmacology CIRM Postdoctoral fellow

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所属学会 (6件)：

International Society for Stem Cell Research , 日本生化学会 , 日本分子生物学会 , 日本血液学会 , International Society for Experimental Hematology , 日本癌学会

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伊藤 貴浩