Takamitsu Yano, Nono Takeuchi-Tomita, Takuya Ueda, Richard H. Haas. Pyrrole-imidazole polyamide, a synthetic DNA-binding compound, is effective at increasing levels of wild-type mtDNA in both cybrid cells and MELAS patient-derived fibroblast cells with the MELAS A3243G mutation by a selective promotion of wild-type replication. MITOCHONDRION. 2013. 13. 6. 924-925
The selective replication activation of wild-type mtDNA by a polyamide compound in cybrid cells and MELAS patient-derived fibroblast cells
(International Symposium on Mitochondria 2013 2013)
The novel therapeutic strategy for mitochondrial DNA disease: A selective promotion of wild-type mitochondrial DNA replication by a synthetic DNA-binding compound
(The Molecular Biology Society of Japan 2011)
Successful preferential propagation of wild-type mitochondrial DNA in human cells harboring the mt tRNALeu(UUR) A3243G mutation by a synthetic DNA-binding compound
(United Mitochondrial Disease Foundation, Mitochondrial Medicine 2011: Chicago 2011)
Normal fibroblast nuclear transfer causes selective loss of mutant mitochondrial DNA harboring the A3243G mutation in human cybrid cells
(The 7th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine (J-mit) 2007)
Preferential loss of mitochondrial DNA harboring the pathogenic mutation tRNALeu(UUR) 3243 A->G in human somatic cell hybrids
(The 5th Annual Conference of the Japanese Society of Mitochondrial Research and Medicine (J-mit) 2005)
