中西博

ナカニシヒロシ | Nakanishi Hiroshi

所属機関・部署：
職名：教授

研究分野 (2件)：常態系口腔科学 , 神経科学一般

研究キーワード (7件)：ミクログリア , 脳炎症 , アルツハイマー病 , ジンジバリス菌 , ジンジパイン , カテプシンB , カテプシンE

競争的資金等の研究課題 (47件)：

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論文 (96件)：

Saori Nonaka, Rin Okamoto, Yui Katsuta, Shiori Kanetsuki, Hiroshi Nakanishi. Gingipain-carrying outer membrane vesicles from Porphyromonas gingivalis cause barrier dysfunction of Caco-2 cells by releasing gingipain into the cytosol. Biochemical and biophysical research communications. 2024. 707. 149783-149783
Erika Inoue, Shiyo Minatozaki, Sachi Shimizu, Sayaka Miyamoto, Misato Jo, Junjun Ni, Hidetoshi Tozaki-Saitoh, Kosuke Oda, Saori Nonaka, Hiroshi Nakanishi. Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L. Cells. 2024. 13. 3. 283-283
Veronika Stoka, Olga Vasiljeva, Hiroshi Nakanishi, Vito Turk. The Role of Cysteine Protease Cathepsins B, H, C, and X/Z in Neurodegenerative Diseases and Cancer. International Journal of Molecular Sciences. 2023. 24. 21. 15613-15613
Wei Kong, Zhen Xie, Xiaokang Shang, Yoshinori Hayashi, Fei Lan, Narengaowa, Shuxuan Zhao, Hui Li, Zhenzhen Quan, Zhou Wu, et al. Zinc finger protein 335 mediates lipopolysaccharide-induced neurodegeneration and memory loss as a transcriptional factor in microglia. Glia. 2023. 71. 12. 2720-2734
Akihiro Matsumoto, Takeo Kitazawa, Yuta Hatori, Hiroshi Nakanishi, Chie Watanabe, Tomoya Takashima, Masahiro Murakami. Targeting cellular gaps using Janus nanoparticles containing cationic polymers and surfactant lipids. Drug Discoveries & Therapeutics. 2023. 17. 2. 104-113

MISC (45件)：

Hiroshi Nakanishi, Zhou Wu. The downward spiral of periodontitis and diabetes in Alzheimer's disease: Extending healthy life expectancy through oral health. Journal of Oral Biosciences. 2015. 57. 3. 139-142
中西博. ミクログリアの産生するカテプシンBの機能的多様性--プロIL-1βのプロセシングと慢性疼痛への関与 (特集インフラマソーム). 生体の科学. 2011. 62. 3. 208-212
ミクログリアとリソソーム病. 脳21. 2003. 6, 15-19
Yoshiro Tomimatsu, Satoru Idemoto, Shigeki Moriguchi, Shigenori Watanabe, Hiroshi Nakanishi. Proteases involved in long-term potentiation. Life Sciences. 2002. 72. 4-5. 355-361
S Moriguchi, S Watanabe, H Kita, H Nakanishi. Enhancement of N-methyl-D-aspartate receptor-mediated excitatory postsynaptic potentials in the neostriatum after methamphetamine sensitization - An in vitro slice study. EXPERIMENTAL BRAIN RESEARCH. 2002. 144. 2. 238-246

書籍 (10件)：

Age-dependent differential activation profiles of glial cells by the leptomeninges during systemic inflammation. In Neuroimmunology Research Focus (Broglio P. V., ed)
Nova Science Publishers, Inc., New York, pp. 101-118. 2007
Microglial Proteases. In: Neural Protein Metabolism and Function. Handbook of Neurochemistry and Molecular Neurobiology, Vol.7 (Lajtha A., ed )
Kluwer Publishing Corporation, New York, pp. 552-564. 2007
Proteases and synaptic activity. In: Proteases in Biology and Disease. Vol.3 (Lendeckel, U. and Hooper, N., eds)
Kluwer Academic/Plenum Publishers, New York, pp.291-310 2004
Involvement of neuronal and microglial proteinases in neuronal death
Recent Research Development in Neurochemistry 1999
Cathepsin E in the central nervous system(jointly worked)
Aspartic Proteinases, Plenum Press 1998

Works (1件)：

学歴 (4件)：

学位 (2件)：

経歴 (8件)：

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所属学会 (8件)：

グリア研究会 , 老化促進モデルマウス(SAM)研究協議会 , 日本脳循環代謝学会 , 基礎歯科学会 , 日本生理学会 , 米国神経科学会 , 日本生化学会 , 日本薬理学会

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中西 博