synthesis of natural product analogs utilizing click chemistry and in situ click chemistry
syntheses of novel chitinase inhibitors
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論文 (53件):
Fumito Sato, Terutaka Sonohara, Shunta Fujiki, Akihiro Sugawara, Yohei Morishita, Taro Ozaki, Teigo Asai. Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (-)-sandaracopimaradiene in the fungus Arthrinium sacchari. Beilstein Journal of Organic Chemistry. 2024
Yue Shi, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Yu Pei Tan, Roger G. Shivas, Rohan A. Davis, Teigo Asai. A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte. Tetrahedron Letters. 2024. 134. 154865-154865
Sho Furumura, Taro Ozaki, Akihiro Sugawara, Yohei Morishita, Kento Tsukada, Tatsuya Ikuta, Asuka Inoue, Teigo Asai. Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase. Journal of Natural Products. 2023. 86. 2. 398-405
Aoi Kimishima, Hiroyasu Ando, Goh Sennari, Yoshihiko Noguchi, Shogo Sekikawa, Toru Kojima, Motoyoshi Ohara, Yoshihiro Watanabe, Yuki Inahashi, Hirokazu Takada, et al. Chemical Degradation-Inspired Total Synthesis of the Antibiotic Macrodiolide, Luminamicin. Journal of the American Chemical Society. 2022
Yuto Homma, Akihiro Sugawara, Yohei Morishita, Kento Tsukada, Taro Ozaki, Teigo Asai. Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach. Organic letters. 2022. 24. 19. 3504-3509
Construction of Silicon Containing Natural Product-like Libraries toward Expanding Chemical Space
(2nd Tohoku University Sichuan University Pharmaceutical Sciences Collaboration Symposium 2019)