水上民夫

“ヒト化酵母”技術による新規創薬標的の同定と阻害剤開発
ヒストンメチル化修飾を標的とするエピジェネティクス制御創薬
Discovery and validation of bio/pharmacogenomic markers for cancer therapeutics and diagnostics.
Identification of molecular targets for oncology drug discovery by chemical genomics.
Searching of novel anticancer drugs modulating functions of epigenetics and proteasome.

Daisuke Ogasawara, Takayoshi Suzuki, Koshiki Mino, Rie Ueda, Mohammed Naseer Ahmed Khan, Takuya Matsubara, Koichi Koseki, Makoto Hasegawa, Ryuzo Sasaki, Hidehiko Nakagawa, et al. Synthesis and biological activity of optically active NCL-1, a lysine-specific demethylase 1 selective inhibitor. BIOORGANIC & MEDICINAL CHEMISTRY. 2011. 19. 12. 3702-3708
Makoto Hasegawa, Tatsuhiro Miura, Kouji Kuzuya, Ayu Inoue, Se Won Ki, Sueharu Horinouchi, Tetsuo Yoshida, Tatsuki Kunoh, Koichi Koseki, Koshiki Mino, et al. Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product. ACS CHEMICAL BIOLOGY. 2011. 6. 3. 229-233
Tatsuki Kunoh, Takanori Noda, Koichi Koseki, Masayuki Sekigawa, Motoki Takagi, Kazuo Shin-ya, Naoki Goshima, Shun-ichiro Iemura, Tohru Natsume, Shu-ichi Wada, et al. A Novel Human Dynactin-Associated Protein, dynAP, Promotes Activation of Akt, and Ergosterol-Related Compounds Induce dynAP-Dependent Apoptosis of Human Cancer Cells. MOLECULAR CANCER THERAPEUTICS. 2010. 9. 11. 2934-2942
Shohei Hamada, Takayoshi Suzuki, Koshiki Mino, Koichi Koseki, Felix Oehme, Ingo Flamme, Hiroki Ozasa, Yukihiro Itoh, Daisuke Ogasawara, Haruka Komaarashi, et al. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. Journal of Medicinal Chemistry. 2010. 53. 15. 5629-5638
Masayuki Sekigawa, Tatsuki Kunoh, Shu-Ichi Wada, Yukio Mukai, Kazuhiko Ohshima, Shinji Ohta, Naoki Goshima, Ryuzo Sasaki, Tamio Mizukami. Comprehensive Screening of Human Genes with Inhibitory Effects on Yeast Growth and Validation of a Yeast Cell-Based System for Screening Chemicals. JOURNAL OF BIOMOLECULAR SCREENING. 2010. 15. 4. 368-378

Mizukami, Tamio; Ito, Seiga; Oka, Tetsuo; Nishi, Tatsunari: Peptides by culturing microorganisms containing recombinant DNA.
Berger, Edward A.; Moss, Bernard; Fuerst, Thomas R.; Mizukami, Tamio; Pastan, Ira H.; Fitzgerald, David J. P.; Chaudhary, Vijay K.: CD4 derivatives for the treatment of infection with human immunodeficiency virus.
Mizukami, Tamio; Asai, Akira; Yamashita, Yoshinori; Katahira, Ritsuko; Hasegawa, Atsuhiro; Ochiai, Keiko; Akinaga, Shiro: Streptomyces UCK14 compounds, their isolation and preparation, and their use as antitumor agents.
Mizukami, Tamio; Sakai, Yasushi; Yoshida, Tetsuo; Agatsuma, Tsutomu; Ochiai, Keiko; Akinaga, Shiro: Antitumor antibiotic GE3.
Mizukami, Tamio; Sakai, Yasushi; Yoshida, Tetsuo; Uosaki, Youichi; Akinaga, Shiro: Herboxidiene derivatives and their preparation from Streptomyces GEX1 culture.

京都大学農学研究科

農学博士

協和発酵工業(株) 東京研究所主任研究員
米国 NIH/NIAID 客員研究員

日本農芸化学会 , 日本薬学会 , 日本分子生物学会 , 日本がん分子標的治療学会 , 日本癌学会

水上 民夫