文献

J-GLOBAL ID：200902226191997069   整理番号：07A0798387

生物分解ゼラチンヒドロゲルを用いた塩基性線維芽細胞成長因子の持続遊離による重大な肢虚血患者に対する治療血管新生の新しい方法 第I-IIa試験の最初の報告

A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel An Initial Report of the Phase I-IIa Study

著者 (14件)： MARUI Akira (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine) ,  TABATA Yasuhiko (Dep. of Biomaterials, Inst. for Frontier Medical Sciences, Kyoto Univ.) ,  KOJIMA Shinsuke (Div. of Clinical Trial Design & Management, Translational Res. Center, Kyoto Univ.) ,  YAMAMOTO Masaya (Dep. of Biomaterials, Inst. for Frontier Medical Sciences, Kyoto Univ.) ,  TAMBARA Keiichi (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine) ,  NISHINA Takeshi (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine) ,  SAJI Yoshiaki (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine) ,  INUI Ken-ichi (Dep. of Pharmacy, Kyoto Univ. Hospital) ,  HASHIDA Tohru (Dep. of Pharmacy, Kyoto Univ. Hospital) ,  YOKOYAMA Sumiko (Dep. of Pharmacy, Kyoto Univ. Hospital) ,  ONODERA Rie (Div. of Clinical Trial Design & Management, Translational Res. Center, Kyoto Univ.) ,  IKEDA Tadashi (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine) ,  FUKUSHIMA Masanori (Div. of Clinical Trial Design & Management, Translational Res. Center, Kyoto Univ.) ,  KOMEDA Masashi (Dep. of Cardiovascular Surgery, Kyoto Univ. Graduate School of Medicine)
資料名： Circulation Journal  (Circulation Journal)
巻： 71  号： 8  ページ： 1181-1186 (J-STAGE)  発行年： 2007年 
JST資料番号： F0908A  ISSN： 1346-9843  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 背景:肢虚血の治療は困難なままである。遺伝子治療または細胞移...

シソーラス用語： 生物分解 ,...
準シソーラス用語： *肢虚血 ,...

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分類 (1件)： 循環系疾患の治療一般  (GJ05010B)

引用文献 (33件)：

• 1. Baumgartner I, Pieczek A, Manor O, Blair R, Kearney M, Walsh K, et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 1114-1123.
• 2. Ruel M, Laham RJ, Parker JA, Post MJ, Ware JA, Simons M, et al. Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J Thorac Cardiovasc Surg 2002; 124: 28-34.
• 3. Losordo DW, Vale PR, Hendel RC, Milliken CE, Fortuin FD, Cummings N, et al. Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia. Circulation 2002; 105: 2012-2018.
• 4. Grines CL, Watkins MW, Helmer G, Penny W, Brinker J, Marmur JD, et al. Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris. Circulation 2002; 105: 1291-1297.
• 5. Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, et al. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): A randomised trial. Lancet 2002; 359: 2053-2058.

タイトルに関連する用語 (9件)： 生物分解 ,  ゼラチンヒドロゲル ,  塩基性線維芽細胞成長因子 ,  肢虚血 ,  患者 ,  治療 ,  血管新生 ,  試験 ,  報告