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J-GLOBAL ID：200902253678789507   整理番号：07A1026741

Chk1キナーゼ阻害剤のピラゾロキノリノン部類の最適化

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

著者 (25件)： BRNARDIC Edward J. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  GARBACCIO Robert M. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  FRALEY Mark E. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  TASBER Edward S. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  STEEN Justin T. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  ARRINGTON Kenneth L. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  DUDKIN Vadim Y. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  HARTMAN George D. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, West Point, PA 19486, USA) ,  STIRDIVANT Steven M. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  DRAKAS Bob A. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  RICKERT Keith (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  WALSH Eileen S. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  HAMILTON Kelly (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  BUSER Carolyn A. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  HARDWICK James (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  TAO Weikang (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  BECK Stephen C. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  MAO Xianzhi (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  LOBELL Robert B. (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  SEPP-LORENZINO Laura (Dep. of Cancer Res., Merck Res. Laboratories, West Point, PA 19486, USA) ,  YAN Youwei (Dep. of Structural Biology, Merck Res. Laboratories, West Point, PA 19486, USA) ,  IKUTA Mari (Dep. of Structural Biology, Merck Res. Laboratories, West Point, PA 19486, USA) ,  MUNSHI Sanjeev K. (Dep. of Structural Biology, Merck Res. Laboratories, West Point, PA 19486, USA) ,  KUO Lawrence C. (Dep. of Structural Biology, Merck Res. Laboratories, West Point, PA 19486, USA) ,  KREATSOULAS Constantine (Dep. of Molecular Systems, Merck Res. Laboratories, West Point, PA 19486, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 17  号： 21  ページ： 5989-5994  発行年： 2007年11月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (4件)： Chk1 ,  キナーゼ阻害剤 ,  部類 ,  最適化