文献

J-GLOBAL ID：200902257958360579   整理番号：09A0636621

非常に強力で選択性で体内吸収されやすい溶解性エポキシドヒドロラーゼ阻害剤としてのスピロ環状第二アミン由来ターシャリーウレア類の発見

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors

著者 (19件)： SHEN Hong C. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  DING Fa-xiang (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  WANG Siyi (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  XU Suoyu (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  CHEN Hsuan-shen (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  TONG Xinchun (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  TONG Vincent (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  MITRA Kaushik (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  KUMAR Sanjeev (Dep. of Drug metabolism, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  ZHANG Xiaoping (Dep. of Metabolic Disorders, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  CHEN Yuli (Dep. of Metabolic Disorders, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  ZHOU Gaochao (Dep. of Metabolic Disorders, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  PAI Lee-yuh (Dep. of Cardiovascular Diseases, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  ALONSO-GALICIA Magdalena (Dep. of Cardiovascular Diseases, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  CHEN Xiaoli (Dep. of Pharmacology, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  ZHANG Bei (Dep. of Metabolic Disorders, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  TATA James R. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  BERGER Joel P. (Dep. of Metabolic Disorders, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA) ,  COLLETTI Steven L. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 19  号： 13  ページ： 3398-3404  発行年： 2009年07月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (6件)： 溶解性 ,  エポキシドヒドロラーゼ ,  阻害剤 ,  環状 ,  第二アミン ,  発見