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J-GLOBAL ID：200902264698113030   整理番号：08A0168419

選択的HDAC1/HDAC2阻害剤(SHI-1:2)によるヒストン脱アセチル化酵素(HDAC)の内部キャビティの探索

Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2)

著者 (26件)： METHOT Joey L. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  CHAKRAVARTY Prasun K. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA) ,  CHENARD Melissa (Dep. of Oncology and Pharmacology, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  CLOSE Joshua (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  CRUZ Jonathan C. (Dep. of Oncology and Pharmacology, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  DAHLBERG William K. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  FLEMING Judith (Dep. of Cancer Biology and Therapeutics, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HAMBLETT Christopher L. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HAMILL Julie E. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HARRINGTON Paul (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HARSCH Andreas (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HEIDEBRECHT Richard (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  HUGHES Bethany (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  JUNG Joon (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  KENIFIC Candia M. (Dep. of Oncology and Pharmacology, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  KRAL Astrid M. (Dep. of Cancer Biology and Therapeutics, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  MEINKE Peter T. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA) ,  MIDDLETON Richard E. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  OZEROVA Nicole (Dep. of Cancer Biology and Therapeutics, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  SLOMAN David L. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  STANTON Matthew G. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  SZEWCZAK Alexander A. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  TYAGARAJAN Sriram (Dep. of Medicinal Chemistry, Merck Res. Laboratories, 126 E. Lincoln Avenue, Rahway, NJ 07065, USA) ,  WITTER David J. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  PAUL SECRIST J. (Dep. of Cancer Biology and Therapeutics, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA) ,  MILLER Thomas A. (Dep. of Drug Design and Optimization, Merck Res. Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 18  号： 3  ページ： 973-978  発行年： 2008年02月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (7件)： HDAC1 ,  HDAC2 ,  阻害剤 ,  ヒストン脱アセチル化酵素 ,  HDAC ,  キャビティ ,  探索