特許
J-GLOBAL ID:200903063862895824
分化多能性増殖間葉系前駆細胞子孫(MEMP)およびその使用
発明者:
,
出願人/特許権者:
代理人 (3件):
平木 祐輔
, 石井 貞次
, 藤田 節
公報種別:公表公報
出願番号(国際出願番号):特願2007-532724
公開番号(公開出願番号):特表2008-520185
出願日: 2005年09月26日
公開日(公表日): 2008年06月19日
要約:
本発明は、発生初期のマーカーSTRO-1briおよびALPによって特徴付けられる分化多能性増殖間葉系前駆細胞子孫(MEMP)に関する。本発明はまた、MEMPの産生方法および治療用途のためのMEMPの使用にも関する。
請求項(抜粋):
全細胞集団の少なくとも10%が、表現型STRO-1bri、ALP-を有する分化多能性増殖間葉系前駆細胞子孫(MEMP)である濃縮細胞集団。
IPC (8件):
C12N 5/06
, C12N 15/09
, A61K 35/12
, A61P 21/00
, A61P 9/00
, A61P 19/00
, A61P 25/00
, A61P 17/00
FI (8件):
C12N5/00 E
, C12N15/00 A
, A61K35/12
, A61P21/00
, A61P9/00
, A61P19/00
, A61P25/00
, A61P17/00
Fターム (23件):
4B024AA01
, 4B024AA11
, 4B024CA04
, 4B024CA20
, 4B024HA11
, 4B065AA90X
, 4B065AC20
, 4B065BA30
, 4B065BB19
, 4B065BB22
, 4B065BB25
, 4B065BB37
, 4B065CA44
, 4C087AA01
, 4C087AA02
, 4C087BB64
, 4C087CA04
, 4C087MA67
, 4C087NA14
, 4C087ZA01
, 4C087ZA36
, 4C087ZA89
, 4C087ZA96
引用文献:
審査官引用 (18件)
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Molecular and cellular characterisation of highly purified stromal stem cells derived from human bon
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Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete dev
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Further characterization of cells expressing STRO-1 in cultures of adult human bone marrow stromal c
-
The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors.
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The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors.
-
The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-d
-
Differential cell surface expression of the STRO-1 and alkaline phosphatase antigens on discrete dev
-
The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-d
-
Isolation and characterization of human clonogenic osteoblast progenitors immunoselected from fetal
-
The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors.
-
Isolation and characterization of human clonogenic osteoblast progenitors immunoselected from fetal
-
Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patien
-
Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patien
-
The growth factor requirements of STRO-1-positive human bone marrow stromal precursors under serum-d
-
Isolation and characterization of human clonogenic osteoblast progenitors immunoselected from fetal
-
Further characterization of cells expressing STRO-1 in cultures of adult human bone marrow stromal c
-
Number and proliferative capacity of osteogenic stem cells are maintained during aging and in patien
-
Further characterization of cells expressing STRO-1 in cultures of adult human bone marrow stromal c
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