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J-GLOBAL ID：201002223765786080   整理番号：10A1108039

前臨床の動物モデルにおける経口有効性ヒドロキシエチルアミン(HEA)BACE-1阻害剤の設計

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

著者 (39件)： TRUONG Anh P. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  TOTH Gergley (Dep. of Molecular Design, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  PROBST Gary D. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  SEALY Jennifer M. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  BOWERS Simeon (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  WONE David W.G. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  DRESSEN Darren (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  HOM Roy K. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  KONRADI Andrei W. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  SHAM Hing L. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  SHAM Hing L. (Dep. of Process and Analytical Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA ...) ,  WU Jing (Dep. of Process and Analytical Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA ...) ,  PETERSON Brian T. (Dep. of Process and Analytical Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA ...) ,  RUSLIM Lany (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  BOVA Michael P. (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  KHOLODENKO Dora (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  MOTTER Ruth N. (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  BARD Frederique (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  SANTIAGO Pamela (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  NI Huifang (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  CHIAN David (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  SORIANO Ferdie (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  COLE Tracy (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  BRIGHAM Elizabeth F. (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  WONG Karina (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  ZMOLEK Wes (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  GOLDBACH Erich (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  SAMANT Bhushan (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  CHEN Linda (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  ZHANG Hongbing (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  NAKAMURA David F. (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  QUINN Kevin P. (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  YEDNOCK Ted A. (Dep. of Medicinal Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  YEDNOCK Ted A. (Dep. of Molecular Design, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA 94080, USA) ,  YEDNOCK Ted A. (Dep. of Process and Analytical Chemistry, Elan Pharmaceuticals, 180 Oyster Point Boulevard, South San Francisco, CA ...) ,  YEDNOCK Ted A. (Dep. of Biology, Elan Pharmaceuticals, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  YEDNOCK Ted A. (Dep. of In Vivo Pharmacology, 800 Gateway Boulevard, South San Francisco, CA 94080, USA) ,  YEDNOCK Ted A. (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...) ,  SAUER John-michael (Dep. of Lead Finding, Drug Disposition, and Safety Evaluation, Elan Pharmaceuticals, 800 Gateway Boulevard, South ...)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 20  号： 21  ページ： 6231-6236  発行年： 2010年11月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (8件)： 臨床 ,  動物 ,  モデル ,  有効性 ,  ヒドロキシエチルアミン ,  BACE ,  阻害剤 ,  設計