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J-GLOBAL ID：201002245758525932   整理番号：10A0729025

ラットにおける睡眠促進活性を有する強力な二重オレキシン受容体拮抗剤としての3,9-ジアザビシクロ[4.2.1]ノナン類の発見

Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat

著者 (16件)： COLEMAN Paul J. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  SCHREIER John D. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  ROECKER Anthony J. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  MERCER Swati P. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  MCGAUGHEY Georgia B. (Chemistry Modeling and Informatics, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  COX Christopher D. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  HARTMAN George D. (Dep. of Medicinal Chemistry, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  HARRELL C. Meacham (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...) ,  REISS Duane R. (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...) ,  DORAN Scott M. (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...) ,  GARSON Susan L. (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...) ,  ANDERSON Wayne B. (Dep. of Drug Metabolism, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  TANG Cuyue (Dep. of Drug Metabolism, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  PRUEKSARITANONT Thomayant (Dep. of Drug Metabolism, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486, USA) ,  WINROW Christopher J. (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...) ,  RENGER John J. (Dep. of Depression and Circadian Disorders, Merck Res. Laboratories, PO Box 4, Sumneytown Pike, West Point, PA 19486 ...)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 20  号： 14  ページ： 4201-4205  発行年： 2010年07月15日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (8件)： ラット ,  睡眠 ,  促進 ,  活性 ,  オレキシン受容体 ,  拮抗剤 ,  ノナン ,  発見