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J-GLOBAL ID：201002248083504611   整理番号：10A0140784

強力なβ-セクレターゼ(BACE1)阻害剤としての5,5′-の2置換性アミノヒダントインの発見と初期最適化

Discovery and initial optimization of 5,5′-disubstituted aminohydantoins as potent β-secretase (BACE1) inhibitors

著者 (24件)： NOWAK Pawel (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  COLE Derek C. (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  AULABAUGH Ann (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  BARD Jonathan (Discovery Neuroscience, Wyeth Res., Princeton, NJ 08852, USA) ,  CHOPRA Rajiv (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  COWLING Rebecca (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  FAN Kristi Y. (Chemical Sciences, Wyeth Res., 865 Ridge Road, Monmouth Junction, NJ 08852, USA) ,  HU Baihua (Chemical Sciences, Wyeth Res., 865 Ridge Road, Monmouth Junction, NJ 08852, USA) ,  JACOBSEN Steve (Discovery Neuroscience, Wyeth Res., Princeton, NJ 08852, USA) ,  JANI Minakshi (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  JIN Guixan (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  LO Mei-chu (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  MALAMAS Michael S. (Chemical Sciences, Wyeth Res., 865 Ridge Road, Monmouth Junction, NJ 08852, USA) ,  MANAS Eric S. (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  NARASIMHAN Rani (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  REINHART Peter (Discovery Neuroscience, Wyeth Res., Princeton, NJ 08852, USA) ,  ROBICHAUD Albert J. (Chemical Sciences, Wyeth Res., 865 Ridge Road, Monmouth Junction, NJ 08852, USA) ,  STOCK Joseph R. (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  SUBRATH Joan (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA) ,  SVENSON Kristine (Chemical Sciences, Wyeth Res., 200 Cambridge Park Drive, Cambridge, MA 02139, USA) ,  TURNER Jim (Discovery Neuroscience, Wyeth Res., Princeton, NJ 08852, USA) ,  WAGNER Erik (Discovery Neuroscience, Wyeth Res., Princeton, NJ 08852, USA) ,  ZHOU Ping (Chemical Sciences, Wyeth Res., 865 Ridge Road, Monmouth Junction, NJ 08852, USA) ,  ELLINGBOE John W. (Chemical Sciences, Wyeth Res., 401 N. Middletown Road, Pearl River, NY 10965, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 20  号： 2  ページ： 632-635  発行年： 2010年01月15日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (6件)： β-セクレターゼ ,  BACE1 ,  阻害剤 ,  発見 ,  初期 ,  最適化