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J-GLOBAL ID：201002255774471678   整理番号：10A0550118

強力なRhoキナーゼ阻害剤としての置換2H-イソキノリン-1-オン パート1 hit-to-lead(ヒット-ツウ-リード)記述

Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account

著者 (15件)： WU Frank (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  BUETTNER Frank H. (Boehringer Ingelheim Pharma GmbH and Co. KG, Birkendorfer Strasse 65, D-88397 Biberach an der Riss, DEU) ,  CHEN Rhonda (Dep. of Cardiometabolic Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT ...) ,  HICKEY Eugene (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  JAKES Scott (Dep. of Cardiometabolic Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT ...) ,  KAPLITA Paul (Dep. of Drug Discovery Support, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  KASHEM Mohammed A. (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  KERR Steven (Dep. of Cardiometabolic Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT ...) ,  KUGLER Stanley (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  PAW Zofia (Dep. of Cardiometabolic Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT ...) ,  PROKOPOWICZ Anthony (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  SHIH Cheng-kon (Dep. of Cardiometabolic Diseases, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT ...) ,  SNOW Roger (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  YOUNG Erick (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA) ,  CYWIN Charles L. (Dep. of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Rd., Ridgefield, CT 06877, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 20  号： 11  ページ： 3235-3239  発行年： 2010年06月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (6件)： Rhoキナーゼ阻害剤 ,  置換 ,  イソキノリン ,  パート ,  リード ,  記述