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J-GLOBAL ID：201002256442717505   整理番号：10A1108040

カテプシンKの2-シアノピリミジン阻害剤の最適化:hERGに対する選択性の改良

Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: Improving selectivity over hERG

著者 (31件)： RANKOVIC Zoran (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  CAI Jiaqiang (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  KERR Jennifer (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  FRADERA Xavier (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  ROBINSON John (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  MISTRY Ashvin (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  FINLAY William (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  MCGARRY George (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  ANDREWS Fiona (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  CAULFIELD Wilson (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  CUMMING Iain (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  DEMPSTER Maureen (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  WALLER John (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  ARBUCKLE Wullie (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  ANDERSON Mark (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  MARTIN Iain (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  MITCHELL Ann (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  LONG Clive (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  BAUGH Mark (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  WESTWOOD Paul (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  KINGHORN Emma (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  JONES Phil (Merck Res. Laboratories, MSD, Newhouse, Lanarkshire, ML1 5SH Scotland, GBR) ,  UITDEHAAG Joost C.M. (Merck Res. Laboratories, MSD, 5340BH Oss, NLD) ,  VAN ZEELAND Mario (Merck Res. Laboratories, MSD, 5340BH Oss, NLD) ,  POTIN Dominique (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  SANIERE Laurent (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  FOUQUET Andre (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  CHEVALLIER Francois (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  DERONZIER Hortense (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  DORLEANS Cecile (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA) ,  NICOLAI Eric (Cerep, 19 avenue du Quebec, 91951 Courtaboeuf cedex, FRA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 20  号： 21  ページ： 6237-6241  発行年： 2010年11月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (4件)： カテプシンK ,  阻害剤 ,  最適化 ,  HERG