Wood, E. R., Truesdale. A. T., McDonald, O. B.. et al.: A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells. Cancer Res.64(18): 6652-6659.2001.
Burris, H. A.3rd., Hurwitz, H. I, Dees, E. G., et al,: Phase I safety, pharmacokinetics, and clinical activity study of lapatinib (GW572016), a reversible dual inhibitor of epidermal growth factor receptor tyrosine kinases, in heavily pretreated patients with metastatic carcinomas. J. Clin. Oncol.23(23): 5305-5313, 2005.