研究者
J-GLOBAL ID：201101054826409362
更新日: 2023年07月28日
南雲 康行
Yasuyuki Nagumo
所属機関・部署：
競争的資金等の研究課題 (5件)：
- 2021 - 2024 独自開発新規κオピオイド受容体作動薬の疼痛緩和医療適用を目指した基盤研究
- 2020 - 2023 オレキシン1受容体選択的作動薬の創出と薬理作用の解明
- 2020 - 2023 オレキシン1受容体を標的としたPETプローブの開発
- 2015 - 2017 末梢神経損傷による視床シナプス外部GABA電流の変化と視床神経回路改編への影響
- 2012 - 2015 神経損傷後の視床神経回路改編と視床細胞活動の関係性-ウイルスベクターによる解析-
論文 (45件)：
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Kenichi Tanaka, Naoko Kuzumaki, Yusuke Hamada, Yukari Suda, Tomohisa Mori, Yasuyuki Nagumo, Minoru Narita. Elucidation of the mechanisms of exercise-induced hypoalgesia and pain prolongation due to physical stress and the restriction of movement. Neurobiology of pain (Cambridge, Mass.). 2023. 14. 100133-100133
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Tsuyoshi Saitoh, Mao Amezawa, Jumpei Horiuchi, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Ryuichiro Ohshita, Akihisa Tokuda, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, et al. Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. European journal of medicinal chemistry. 2022. 240. 114505-114505
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Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, et al. Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. Bioorganic & medicinal chemistry letters. 2022. 60. 128555-128555
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Keita Iio, Tsuyoshi Saitoh, Ryuichiro Ohshita, Tsubasa Hino, Mao Amezawa, Yoshiaki Takayama, Yasuyuki Nagumo, Naoshi Yamamoto, Noriki Kutsumura, Yoko Irukayama-Tomobe, et al. <p>Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring</p>. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2022. 60
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Koki Katoh, Naoshi Yamamoto, Yukiko Ishikawa, Yoko Irukayama-Tomobe, Ryuji Tanimura, Tsuyoshi Saitoh, Yasuyuki Nagumo, Noriki Kutsumura, Masashi Yanagisawa, Hiroshi Nagase. Effect of removal of the 14-hydroxy group on the affinity of the 4,5-epoxymorphinan derivatives for orexin and opioid receptors. Bioorganic & medicinal chemistry letters. 2022. 59. 128527-128527
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MISC (27件)：
特許 (1件)：
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<産業財産権・特許>特願 2016-155477,モルヒナン誘導体及びその医薬用途
書籍 (1件)：
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トワイクロス先生のがん緩和ケア処方薬 : 薬効・薬理と薬の使い方
医学書院 2013 ISBN:9784260015219
学位 (1件)：
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