3) Chapman PB, Hauschild A, Robert C, et a1. lm- proved survival with vemurafenib in melanoma with BRAF V600E mutation. N Eng1 J Med 2011 ; 364 : 2507.
4) McDermott DF, Sosman JA, Gonzalez R, et al. Double一blind randomized phase II study of the com- bination of sorafenib and dacarbazine in patients with advanced melanoma : a report from the 11715 Study Group. J Clin Onco12008 ; 26 : 2178.