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J-GLOBAL ID：201202251404970275   整理番号：12A1077752

PIM-1、PIM-2およびPIM-3タンパク質キナーゼの強力かつ選択的阻害剤としての新規ベンジリデン-1,3-チアゾリジン-2,4-ジオンの発見

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

著者 (18件)： DAKIN Les A. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  BLOCK Michael H. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  CHEN Huawei (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  CODE Erin (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  DOWLING James E. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  FENG Xiaomei (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  FERGUSON Andrew D. (Discovery Sciences - Structure and Biophysics, AstraZeneca, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  GREEN Isabelle (Discovery Sciences - Reagents and Assay Dev., AstraZeneca, Alderley Park, Cheshire SK10 4TG, GBR) ,  HIRD Alexander W. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  HOWARD Tina (Discovery Sciences - Structure and Biophysics, AstraZeneca, Alderley Park, Cheshire SK10 4TG, GBR) ,  KEETON Erika K. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  LAMB Michelle L. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  LYNE Paul D. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  POLLARD Hannah (Discovery Sciences - Reagents and Assay Dev., AstraZeneca, Alderley Park, Cheshire SK10 4TG, GBR) ,  READ Jon (Discovery Sciences - Structure and Biophysics, AstraZeneca, Alderley Park, Cheshire SK10 4TG, GBR) ,  WU Allan J. (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  ZHANG Tao (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA) ,  ZHENG Xiaolan (Oncology iMed Sciences Group, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 22  号： 14  ページ： 4599-4604  発行年： 2012年07月15日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (9件)： Pim-1 ,  Pim-2 ,  PIM ,  タンパク質キナーゼ ,  阻害剤 ,  ベンジリデン ,  チアゾリジン ,  ジオン ,  発見