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J-GLOBAL ID：201202258605518898   整理番号：12A0878044

強力かつ経口投与で有効なS1P₃温存S1P₁アゴニストとしての1,3-チアゾリルチオフェンおよびピリジン誘導体の合成とSAR

Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P₃-sparing S1P₁ agonists

著者 (22件)： ASANO Masayoshi (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  NAKAMURA Tsuyoshi (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  SEKIGUCHI Yukiko (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  MIZUNO Yumiko (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  YAMAGUCHI Takahiro (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  TAMAKI Kazuhiko (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  SHIMOZATO Takaichi (Frontier Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  DOI-KOMURO Hiromi (Frontier Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  KAGARI Takashi (Frontier Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  TOMISATO Wataru (Frontier Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  INOUE Ryotaku (Frontier Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  YUITA Hiroshi (Oncology Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  OGUCHI-OSHIMA Keiko (Oncology Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  KANEKO Reina (Global Project Management Dep., Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  NARA Futoshi (Cardiovascular Metabolics Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710 ...) ,  KAWASE Yumi (Cardiovascular Metabolics Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710 ...) ,  MASUBUCHI Noriko (Drug Metabolism & Pharmacokinetics Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  NAKAYAMA Shintaro (Drug Metabolism & Pharmacokinetics Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...) ,  KOGA Tetsufumi (Biological Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  NAMBA Eiko (Biological Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  NASU Hatsumi (Biological Res. Laboratories, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, JPN) ,  NISHI Takahide (Lead Discovery & Optimization Res. Laboratories I, Daiichi Sankyo Co., Ltd, 1-2-58 Hiromachi, Shinagawa-ku, Tokyo ...)
資料名： Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)
巻： 22  号： 9  ページ： 3083-3088  発行年： 2012年05月01日 
JST資料番号： W0248A  ISSN： 0960-894X  資料種別： 逐次刊行物 (A)
発行国： オランダ (NLD)  言語： 英語 (EN)

タイトルに関連する用語 (3件)： 経口投与 ,  ピリジン誘導体 ,  SAR