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J-GLOBAL ID：201202295462599070   整理番号：12A1194624

冠動脈疾患:中国漢民族でのゲノムワイド関連研究から冠動脈疾患の4個の新規感受性座位が同定される

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

著者 (40件)： LU Xiangfeng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  WANG Laiyuan (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CHEN Shufeng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  YANG Xueli (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  HUANG Jianfeng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LI Jianxin (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CAO Jie (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CHEN Jichun (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  GE Dongliang (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LI Ying (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  ZHAO Liancheng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CHEN Lanying (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LIU Donghua (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CHEN Jingping (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  DUAN Xiufang (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  HAO Yongchen (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  ZHAO Qi (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  YU Dahai (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  WANG Qianqian (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  YANG Ying (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LIU Fangchao (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  MAO Qunxia (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LIANG Xiaohua (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  JI Jingfeng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  MO Xingbo (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LI Dianjiang (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  CHAI Guoping (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  LI Xiangdong (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  DU Zhenhan (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  WU Xigui (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  GU Dongfeng (National Center of Cardiovascular Diseases, Chinese Acad. of Medical Sci. and Peking Union Medical Coll., Beijing, CHN) ,  WANG Laiyuan (National Human Genome Center at Beijing, Beijing, CHN) ,  LI Hongfan (National Human Genome Center at Beijing, Beijing, CHN) ,  LIU Xuehui (National Human Genome Center at Beijing, Beijing, CHN) ,  DOU Chenlong (National Human Genome Center at Beijing, Beijing, CHN) ,  HE Lin (Shanghai Jiao Tong Univ., Shanghai, CHN) ,  SHI Yongyong (Shanghai Jiao Tong Univ., Shanghai, CHN) ,  CHENG Jing (National Engineering Res. Center for Beijing Biochip Technol. (NERCBBT), Beijing, CHN) ,  ZHANG Liang (National Engineering Res. Center for Beijing Biochip Technol. (NERCBBT), Beijing, CHN) ,  CHENG Jing (Tsinghua Univ., Beijing, CHN)
資料名： Nature Genetics  (Nature Genetics)
巻： 44  号： 8  ページ： 890-894  発行年： 2012年08月 
JST資料番号： W0430A  ISSN： 1061-4036  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 症例1,515人および対照5,019人からなる冠動脈疾患の2つのゲノムワイド関連研究のメタ解析を行い,次に,症例15,460人および対照11,472人において追試を行った(被験者はすべて中国漢民族系である)。ゲノムワイドな有意水準の閾値(P<5×10^-8)に達した冠動脈疾患の4個の新規座位を同定したので報告する。同定した座位は,TTC32-WDR35,GUCY1A3,C6orf10-BTNL2,ATP2B1の内またはその近傍に位置決定された。また,これまでにヨーロッパ人集団において同定された4座位の再現性も得た(PHACTR1,TCF21,CDKN2A-CDKN2B,C12orf51の内またはその近傍)。これらの知見は,中国漢民族集団における冠動脈疾患の感受性に寄与する経路についての新しい手がかりとなる。Copyright Nature Publishing Group 2012

シソーラス用語： 中華人民共和国 ,  民族 ,  *冠動脈疾患 ,  遺伝学実験技術 ,  症例対照研究 ,  *遺伝子座 ,  危険因子 ,  ヒト ,  メタ分析 ,  ゲノムワイド関連解析
準シソーラス用語： 漢民族

分類 (1件)： 遺伝的変異  (EC01030Y)

タイトルに関連する用語 (8件)： 冠動脈疾患 ,  中国 ,  民族 ,  ゲノム ,  研究 ,  感受性 ,  座位 ,  同定