文献

J-GLOBAL ID：201302245716217482   整理番号：13A1928862

人工多能性幹細胞から分化した肝細胞様細胞において肝細胞核因子6はCYP3A4の転写を活性化する

Hepatocyte Nuclear Factor 6 Activates the Transcription of CYP3A4 in Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells

著者 (11件)： SASAKI Takamitsu (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  TAKAHASHI Shogo (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  NUMATA Yoshihiro (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  NARITA Masayo (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  TANAKA Yutaka (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  KUMAGAI Takeshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.) ,  KONDO Yuki (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  MATSUNAGA Tamihide (Dep. of Clinical Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City Univ.) ,  OHMORI Shigeru (Dep. of Molecular Pharmacology, Shinshu Univ. Graduate School of Medicine) ,  OHMORI Shigeru (Dep. of Pharmacy, Shinshu Univ. Hospital) ,  NAGATA Kiyoshi (Dep. of Environmental and Health Sci., Tohoku Pharmaceutical Univ.)
資料名： Drug Metabolism and Pharmacokinetics  (Drug Metabolism and Pharmacokinetics)
巻： 28  号： 3  ページ： 250-259 (J-STAGE)  発行年： 2013年 
JST資料番号： X0758A  ISSN： 1347-4367  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 人工多能性幹細胞(iPSC)は薬物代謝研究に応用される肝細胞...

シソーラス用語： 幹細胞 ,...
準シソーラス用語： *CYP3A4 ,...

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分類 (2件)： 消化器の基礎医学  (GH01020E) ,  細胞生理一般  (EF02010S)

引用文献 (53件)：

• 1) Donato, M. T., Lahoz, A., Castell, J. V. and Gomez-Lechon, M. J.: Cell lines: a tool for in vitro drug metabolism studies. Curr. Drug Metab., 9: 1–11 (2008).
• 2) LeCluyse, E., Madan, A., Hamilton, G., Carroll, K., Dehaan, R. and Parkinson, A.: Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J. Biochem. Mol. Toxicol., 14: 177–188 (2000).
• 3) Aninat, C., Piton, A., Glaise, D., Le Charpentier, T., Langouet, S., Morel, F., Guguen-Guillouzo, C. and Guillouzo, A.: Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug Metab. Dispos., 34: 75–83 (2006).
• 4) Funakoshi, N., Duret, C., Pascussi, J. M., Blanc, P., Maurel, P., Daujat-Chavanieu, M. and Gerbal-Chaloin, S.: Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes. Stem Cell Rev., 7: 518–531 (2011).
• 5) Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S.: Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell, 131: 861–872 (2007).

タイトルに関連する用語 (7件)： 人工多能性幹細胞 ,  分化 ,  肝細胞様細胞 ,  肝細胞核因子6 ,  CYP3A4 ,  転写 ,  活性化