文献

J-GLOBAL ID：201302275169585877   整理番号：13A0637883

カルノシン酸はSH-SY5Yヒト神経芽腫細胞においてメタロプロテアーゼ遺伝子TACE/ADAM17を誘導することによりアミロイド-β1ー42の産生を抑制する

Carnosic acid suppresses the production of amyloid-β 1-42 by inducing the metalloprotease gene TACE/ADAM17 in SH-SY5Y human neuroblastoma cells

著者 (14件)： MENG Pengfei (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  YOSHIDA Hidemi (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  MATSUMIYA Tomoh (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  IMAIZUMI Tadaatsu (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  TANJI Kunikazu (Dep. of Neuropathology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, Hirosaki 036-8562, JPN) ,  XING Fei (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  HAYAKARI Ryo (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...) ,  DEMPOYA Junichi (Dep. of Cardiology, Respiratory Medicine and Nephrology, Hirosaki Univ. Graduate School of Medicine, Hirosaki ...) ,  TATSUTA Tetsuya (Dep. of Gastroenterology and Hematology, Hirosaki Univ. Graduate School of Medicine, Hirosaki 036-8562, JPN) ,  AIZAWA-YASHIRO Tomomi (Dep. of Pediatrics, Hirosaki Univ. Graduate School of Medicine, Hirosaki 036-8562, JPN) ,  MIMURA Junsei (Dep. of Stress Response Sci., Hirosaki Univ. Graduate School of Medicine, Hirosaki 036-8562, JPN) ,  KOSAKA Kunio (Res. and Dev. Center, Nagase & Co. Ltd., 2-2-3, Kobe 651-2241, JPN) ,  ITOH Ken (Dep. of Stress Response Sci., Hirosaki Univ. Graduate School of Medicine, Hirosaki 036-8562, JPN) ,  SATOH Kei (Dep. of Vascular Biology, Inst. of Brain Sci., Hirosaki Univ. Graduate School of Medicine, 5 Zaifu-cho, Hirosaki ...)
資料名： Neuroscience Research  (Neuroscience Research)
巻： 75  号： 2  ページ： 94-102  発行年： 2013年02月 
JST資料番号： D0210C  ISSN： 0168-0102  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： Alzheimer病(AD)の指標は,アミロイドβ前駆ペプチ...

シソーラス用語： 培養細胞 ,...
準シソーラス用語： mRNA発現 ,...

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分類 (3件)： 中枢神経系  (EJ12030F) ,  神経系の疾患  (GN03000O) ,  生物学的機能  (EB03040U)

物質索引 (1件)： カルノシン酸

引用文献 (43件)：

• Ahmad, M., Takino, T., Miyamori, H., Yoshizaki, T., Furukawa, M., Sato, H., 2006. Cleavage of amyloid-β precursor protein (APP) by membrane-type matrix metalloproteinases. J. Biochem. 139, 517-526.
• Amour, A., Knight, C.G., English, W.R., Webster, A., Slocombe, P.M., Knäuper, V., Docherty, A.J.P., Becherer, J.D., Blobel, C.P., Murphy, G., 2002. The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPs. FEBS Lett. 524, 154-158.
• Bitan, G., Kirkitadze, M.D., Lomakin, A., Vollers, S.S., Benedek, G.B., Teplow, D.B., 2002. Amyloid β-protein (Aβ) assembly Aβ 40 and Aβ 42 oligomerize through distinct pathways. Proc. Natl. Acad. Sci. U. S. A. 100, 330-335.
• Buxbaum, J.D., Liu, K.-N., Luo, Y., Slack, J.L., Stocking, K.L, Peschon, J.J., Johnson, R.S., Castner, B.J., Cerretti, D.P., Black, R.A., 1998. Evidence that tumor necrosis factor a converting enzyme is involved in regulated α-secretase cleavage of the Alzheimer amyloid protein precursor. J. Biol. Chem. 273, 27765-27767.
• Fahrenholz, F., 2007. Alpha-secretase as a therapeutic target. Curr. Alzheimer Res. 4, 412-417.

タイトルに関連する用語 (9件)： カルノシン酸 ,  ヒト ,  神経芽腫細胞 ,  メタロプロテアーゼ ,  遺伝子 ,  TACE ,  ADAM17 ,  誘導 ,  アミロイド