1) Boku N, Yamamoto S, Fukuda H, et al: Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer: a randomized phase 3 study. Lancet Oncol 10: 1063-1069, 2009
2) Koizumi W, Narahara H, Hara T, et al: S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial) : a phase III trial. Lancet Oncol 9: 215-221, 2008
3) Bang YJ, Van Cutsem E, Feyereislova A, et al: Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastrooesophageal junction cancer (ToGA) : a phase 3, open-label, randomised controlled trial. Lancet 376: 687-697, 2010
4) Murad AM, Santiago FF, Petroianu A, et al: Modi-fied therapy with 5-fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer. Cancer 72: 37-41, 1993
5) Scheithauer W, Kornek G, Zek B, et al: Palliative chemotherapy versus supportive care in patients with metastatic gastric cancer: A randomized trial, Second Int Conf Biol, Prev, Treatm GI Malignancy, Koln, Germany 68 (Abstract) , 1995