山門穂高

Yamakado Hodaka

所属機関・部署：
職名：特定准教授

研究分野 (1件)：神経内科学

研究キーワード (6件)：プリオン , α-シヌクレイン , バイオマーカー , 動物モデル , 多系統萎縮症 , パーキンソン病

競争的資金等の研究課題 (11件)：

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論文 (65件)：

Ryoko Kobayashi, Kotaro Kamitani, Masanori Sawamura, Hodaka Yamakado, Ryosuke Takahashi, Masayuki Sohgawa, Minoru Noda. A Rapid, Sensitive, and Specific Detection of Aggregated α-Synuclein by a Liposome-Immobilized Cantilever Sensor. IEEE Sensors Journal. 2023. 23. 12. 12495-12502
Masanori Sawamura, Junichiro Ohira, Rie Hikawa, Tomoyuki Ishimoto, Etsuro Nakanishi, Hodaka Yamakado, Ryosuke Takahashi. Single-dose intranasal administration of α-syn PFFs induce lewy neurite-like pathology in olfactory bulbs. Parkinsonism & related disorders. 2023. 112. 105440-105440
Tatsuya Ikenoue, Miki Oono, Masatomo So, Hodaka Yamakado, Toshiaki Arata, Ryosuke Takahashi, Yasushi Kawata, Hiroaki Suga. A RaPID Macrocyclic Peptide That Inhibits the Formation of α-Synuclein Amyloid Fibrils. Chembiochem : a European journal of chemical biology. 2023. e202300320
Jun Ueda, Norihito Uemura, Tomoyuki Ishimoto, Tomoyuki Taguchi, Masanori Sawamura, Etsuro Nakanishi, Masashi Ikuno, Shuichi Matsuzawa, Hodaka Yamakado, Ryosuke Takahashi. Ca2+ -Calmodulin-Calcineurin Signaling Modulates α-Synuclein Transmission. Movement disorders. 2023
Mingyue Jin, Sakiko Matsumoto, Takashi Ayaki, Hodaka Yamakado, Tomoyuki Taguchi, Natsuko Togawa, Ayumu Konno, Hirokazu Hirai, Hiroshi Nakajima, Shoji Komai, et al. DOPAnization of tyrosine in α-synuclein by tyrosine hydroxylase leads to the formation of oligomers. Nature communications. 2022. 13. 1. 6880-6880

MISC (9件)：

引網亮太, 端祐一郎, 山門穂高, 辰己新水, 山下博史, 澤本伸克, 辻輝之, 川本未知, 幸原伸夫, 井上治久, et al. FUS遺伝子変異を伴う筋萎縮性側索硬化症の臨床像:若年発症例を含む4症例の検討. 56th Annual Meeting of the Japanese Society of Neurology, Niigata. 2015
Yasushi Koshiba, Hodaka Yamakado, Asuka Morizane, Tetsuhiro Kikuchi, Kazuko Hasegawa, Haruhisa Inoue, Jun Takahashi, Ryosuke Takahashi. iPS cell modeling of genetic Parkinson's disease. MOVEMENT DISORDERS. 2014. 29. S68-S68
N. Uemura, H. Matsui, T. Fujiwara-Ishikawa, M. Kinoshita, M. Koike, H. Yamakado, K. Uemura, Y. Uchiyama, T. Todo, S. I. Takeda, et al. Viable Gaucher's disease model of medaka fish completely deficienct in glucocerebrosidase activity developed alpha-synuclein aggregation in the brain. MOVEMENT DISORDERS. 2013. 28. S373-S374
H. Yamakado, Y. Moriwaki, N. Yamasaki, T. Miyakawa, J. Kurisu, K. Uemura, H. Inoue, M. Takahashi, R. Takahashi. alpha-synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior. MOVEMENT DISORDERS. 2012. 27. S498-S498
Roberto Gavinio, Hodaka Yamakado, Tomoyo Sawada, Makio Takahashi, Ryosuke Takahashi. Pael-R, a substrate of Parkin, can also be cleared by PINK1. NEUROSCIENCE RESEARCH. 2011. 71. E192-E192

講演・口頭発表等 (15件)：

神経変性疾患における中枢-末梢病態連関
(第46回神経科学大会(シンポジウム) 2023)
パーキンソン病に伴う自律神経障害
(第75回日本自律神経学会総会(シンポジウム) 2022)
Animal model for Parkinson's disease: Strengths and drawbacks
(UK-Japan Neuroscience Symposium 2022)
多系統萎縮症の病態はどこまで分かったか?
(第16回MDSJ(教育講演) 2022)
Animal model of Parkinson's disease: For unveiling the pathogenesis and the develpment of DMT
(第63回日本神経学会総会(シンポジウム) 2022)

学歴 (2件)：

学位 (1件)：

経歴 (8件)：

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山門 穂高