天野孝紀

アマノタカノリ | Amano Takanori

所属機関・部署：
職名：チームリーダー

研究分野 (2件)：遺伝学 , ゲノム生物学

研究キーワード (4件)：多因子疾患 , 疾患モデルマウス , エンハンサー , 遺伝子発現制御

競争的資金等の研究課題 (5件)：

論文 (25件)：

Reimi Tada, Takuya Higashidate, Takanori Amano, Shoma Ishikawa, Chifuyu Yokoyama, Suzu Kobari, Saki Nara, Koshiro Ishida, Akane Kawaguchi, Haruki Ochi, et al. The shh limb enhancer is activated in patterned limb regeneration but not in hypomorphic limb regeneration in Xenopus laevis. Developmental Biology. 2023
Shigekazu Tanaka, Hajime Orita, Taro Kataoka, Masahiro Miyazaki, Harumi Saeki, Ryo Wada, Malcolm V Brock, Tetsu Fukunaga, Takanori Amano, Toshihiko Shiroishi. Gasdermin D Represses Inflammation-Induced Colon Cancer Development by Regulating Apoptosis. Carcinogenesis. 2023
Takanori Amano. Gene regulatory landscape of the sonic hedgehog locus in embryonic development. Development, growth & differentiation. 2020. 62. 5. 334-342
Sagai T, Amano T, Maeno A, Ajima R, Shiroishi T. SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization. Proceedings of the National Academy of Sciences of the United States of America. 2019. 116. 47. 23636-23642
Okuhara S, Birjandi AA, Adel Al-Lami H, Sagai T, Amano T, Shiroishi T, Xavier GM, Liu KJ, Cobourne MT, Iseki S. Temporospatial sonic hedgehog signalling is essential for neural crest-dependent patterning of the intrinsic tongue musculature. Development (Cambridge, England). 2019. 146. 21

MISC (11件)：

Kousuke Mouri, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi. Orientation-dependent enhancer evoked by chromosomal translocation in mouse Hm mutation. MECHANISMS OF DEVELOPMENT. 2017. 145. S139-S139
Takanori Amano, Toshihiko Shiroishi. Cis-regulatory polymorphism of Shh is involved in variation of shape and size of the mouse stomach. GENES & GENETIC SYSTEMS. 2016. 91. 6. 351-351
Tomoko Sagai, Takanori Amano, Akiteru Maeno, Youichi Mizushina, Hiromi Nakazawa, Toshihiko Shiroishi. Dosage effect of two Shh enhancers for control of tooth number in mouse. GENES & GENETIC SYSTEMS. 2016. 91. 6. 353-353
Kousuke Mouri, Tomoko Sagai, Takanori Amano, Toshihiko Shiroishi. Enhancer rearrangement causes regulatory change of gene expression. GENES & GENETIC SYSTEMS. 2016. 91. 6. 373-373
Takanori Amano. A genome-editing approach using the CRISPR/Cas9 system reveals the cis-regulatory landscape of the mouse Shh locus. GENES & GENETIC SYSTEMS. 2015. 90. 6. 362-362

特許 (1件)：

書籍 (4件)：

講演・口頭発表等 (18件)：

Shh遺伝子の発現を制御する染色体高次構造の動態
(東北大学加齢医学研究所研究員会セミナー 2011)
Long-rangeエンハンサーによるShh遺伝子の発現制御
(みんなで建設的に考える会 2011)
A BAC-transgenic mouse model for the long-range enhancer-promoter interaction at the Shh locus
(第44回日本発生生物学会年会 2011)
A mouse mutation Rim4 with duplication of a 7Mb segment of chromosome 8 is model of Partial trisomy 4q-ter syndrome that exhibits congenital malformation
(23th INTERNATIONAL MOUSE GENOME CONFERENCE 2009 2009)
Long-range enhancer-promoter interaction via chromosomal dynamics at the Shh locus
(23th INTERNATIONAL MOUSE GENOME CONFERENCE 2009 2009)

学歴 (3件)：

学位 (1件)：

経歴 (3件)：

2018/07 - 現在 RIKEN BioResource Research Center 次世代ヒト疾患モデル研究開発チームチームリーダー
2013/11 - 2018/03 国立遺伝学研究所哺乳動物遺伝研究室助教
2005/04 - 2013/10 National Institute of Genetics Mammalian Genetics Laboratory 研究員

所属学会 (2件)：

日本遺伝学会 , 日本発生生物学会

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天野 孝紀