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J-GLOBAL ID：201402263607025790   整理番号：14A1122982

進行性前立腺癌患者由来のオルガノイド培養

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

著者 (40件)： GAO Dong (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  VELA Ian (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  VELA Ian (Urology Serv., Dep. of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  SBONER Andrea (Inst. for Computational Biomedicine, Weill Cornell Medical Coll., New York, NY 10065, USA) ,  SBONER Andrea (Inst. for Precision Medicine of Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  SBONER Andrea (Dep. of Pathology and Lab. Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY ...) ,  IAQUINTA Phillip J. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  KARTHAUS Wouter R. (Hubrecht Inst., Royal Netherlands Acad. of Arts and Sciences and Univ. Medical Center Utrecht, 3584 CT, Utrecht, NLD) ,  GOPALAN Anuradha (Dep. of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  DOWLING Catherine (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  DOWLING Catherine (Urology Serv., Dep. of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  WANJALA Jackline N. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  UNDVALL Eva A. (Lab. Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  ARORA Vivek K. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  ARORA Vivek K. (Dep. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  WONGVIPAT John (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  KOSSAI Myriam (Dep. of Pathology and Lab. Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY ...) ,  RAMAZANOGLU Sinan (Inst. for Computational Biomedicine, Weill Cornell Medical Coll., New York, NY 10065, USA) ,  RAMAZANOGLU Sinan (Dep. of Pathology and Lab. Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY ...) ,  BARBOZA Luendreo P. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  DI Wei (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  CAO Zhen (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  ZHANG Qi Fan (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  SIROTA Inna (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  RAN Leili (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  MACDONALD Theresa Y. (Dep. of Pathology and Lab. Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY ...) ,  BELTRAN Himisha (Inst. for Precision Medicine of Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  BELTRAN Himisha (Dep. of Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  MOSQUERA Juan-miguel (Inst. for Precision Medicine of Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  MOSQUERA Juan-miguel (Dep. of Pathology and Lab. Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY ...) ,  TOUIJER Karim A. (Urology Serv., Dep. of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  SCARDINO Peter T. (Urology Serv., Dep. of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  LAUDONE Vincent P. (Urology Serv., Dep. of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  CURTIS Kristen R. (Dep. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  RATHKOPF Dana E. (Dep. of Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  RATHKOPF Dana E. (Dep. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  MORRIS Michael J. (Dep. of Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  MORRIS Michael J. (Dep. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA) ,  DANILA Daniel C. (Dep. of Medicine, Weill Cornell Medical Coll. and New York-Presbyterian Hospital, New York, NY 10065, USA) ,  DANILA Daniel C. (Dep. of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 159  号： 1  ページ： 176-187  発行年： 2014年09月25日 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： ヒト前立腺癌の多様性を再現するin vitro前立腺癌モデルがないことで,疾病病因と治療反応の解明の進行が妨げられてきた。三次元オルガノイド系を用いて著者らは,生検組織由来の前立腺癌と循環腫瘍細胞の長期培養の成功を報告する。完全に特徴付けした7つのオルガノイド株は,TMPRSS2-ERG融合,SPOP突然変異,SPINK1過剰発現,CHD1喪失を含む前立腺癌亜型の分子的多様性を再現した。全エクソーム解析はゲノム研究と一致して低い変異性負荷を示すが,FOXA1とPIK3R1に加えて,進行性疾患で報告されているDNA修復経路とクロマチン修飾因子経路で突然変異を示した。P53とRB腫瘍抑制因子経路機能の喪失が最も多くみられる特徴で,オルガノイド株全体で共通して見られた。本稿で述べられている方法は遺伝学的研究および薬理的研究の対象となる患者由来前立腺癌株の幅広いレパートリーの生成を可能にするはずである。Copyright 2014 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.

シソーラス用語： ヒト ,  *進行癌 ,  *前立腺腫瘍 ,  腫瘍細胞 ,  *生体組織 ,  *細胞培養 ,  性質 ,  突然変異 ,  ゲノム ,  スクリーニング
準シソーラス用語： エクソーム ,  *オルガノイド ,  *三次元培養 ,  *進行性前立腺癌 ,  分子多様性 ,  変異スクリーニング

分類 (4件)： 泌尿生殖器の腫よう  (GM04000S) ,  基礎腫よう学一般  (GE02010R) ,  遺伝的変異  (EC01030Y) ,  細胞・組織培養法  (EA03040R)

タイトルに関連する用語 (4件)： 進行性前立腺癌 ,  患者 ,  オルガノイド ,  培養