文献

J-GLOBAL ID：201602218346696061   整理番号：16A1395625

成体マウスにおける広範および一時的な遺伝子改変のためのタモキシフェン誘導Cre-driverマウス系統の確立

Establishment of a tamoxifen-inducible Cre-driver mouse strain for widespread and temporal genetic modification in adult mice

著者 (8件)： Ichise Hirotake (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Hori Akiko (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Shiozawa Seiji (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kondo Saki (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Kanegae Yumi (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Saito Izumu (Laboratory of Molecular Genetics, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Ichise Taeko (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan) ,  Yoshida Nobuaki (Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan)
資料名： Experimental Animals  (Experimental Animals)
巻： 65  号： 3  ページ： 231-244(J-STAGE)  発行年： 2016年 
JST資料番号： Z0755A  ISSN： 1341-1357  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： リガンド誘導性Cre/loxPシステムを用いたマウスにおける...

シソーラス用語： *遺伝子操作 ,...
準シソーラス用語： Cre/loxP ,...

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著者キーワード (5件)： FLP/FRT ,  mouse ,  SV40 large T antigen ,  tamoxifen-inducible Cre ,  tumorigenesis

分類 (1件)： 遺伝子操作  (EC02050B)

物質索引 (1件)： タモキシフェン

引用文献 (30件)：

• 1. Anastassiadis K., Glaser S., Kranz A., Berhardt K., and Stewart A.F. 2010. A practical summary of site-specific recombination, conditional mutagenesis, and tamoxifen induction of CreERT2. Methods Enzymol. 477: 109-123.
• 2. Donehower L.A., Harvey M., Slagle B.L., McArthur M.J., Montgomery C.A. Jr., Butel J.S., and Bradley A. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356: 215-221.
• 3. Feil R., Brocard J., Mascrez B., LeMeur M., Metzger D., and Chambon P. 1996. Ligand-activated site-specific recombination in mice. Proc. Natl. Acad. Sci. USA 93: 10887-10890.
• 4. Friedrich G. and Soriano P. 1991. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5: 1513-1523.
• 5. Hayashi S. and McMahon A.P. 2002. Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev. Biol. 244: 305-318.

タイトルに関連する用語 (7件)： 成体 ,  マウス ,  遺伝子改変 ,  タモキシフェン ,  誘導 ,  Cre ,  系統