文献

J-GLOBAL ID：201602233728146647   整理番号：16A1175913

結腸直腸癌患者から得た循環無細胞DNAを用いたKRAS突然変異検出の有用性

Utility of KRAS mutation detection using circulating cell-free DNA from patients with colorectal cancer

著者 (15件)： Yamada Takeshi (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Iwai Takuma (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Takahashi Goro (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Kan Hayato (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Koizumi Michihiro (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Matsuda Akihisa (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Shinji Seiichi (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Yamagishi Aya (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Yokoyama Yasuyuki (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Tatsuguchi Atsushi (Department of Gastroenterology, Nippon Medical School, Tokyo, Japan) ,  Kawagoe Tatsuro (Department of Gastroenterology, Nippon Medical School, Tokyo, Japan) ,  Kitano Shiro (Technical Research Institute, Toppan Printing Co. Ltd., Saitama, Japan) ,  Nakayama Masato (Technical Research Institute, Toppan Printing Co. Ltd., Saitama, Japan) ,  Matsumoto Satoshi (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan) ,  Uchida Eiji (Department of Gastrointestinal and Hepato-Biliary-Pancreatic Surgery, Nippon Medical School, Tokyo, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 107  号： 7  ページ： 936-943  発行年： 2016年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 本研究で著者らは転移性結腸直腸癌患者の循環無細胞(ccf)D...

シソーラス用語： *結腸腫瘍 ,...
準シソーラス用語： *結腸直腸癌 ,...

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著者キーワード (5件)： Anti-EGFR antibody ,  circulating cell-free DNA ,  circulating tumor DNA ,  EGFR blockade ,  KRAS

分類 (3件)： 腫ようの化学・生化学・病理学  (GE02030N) ,  消化器の腫よう  (GH04000D) ,  分子遺伝学一般  (EC02010J)

引用文献 (32件)：

• Cunningham D, Humblet Y, Siena S et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-45.
• Lievre A, Bachet JB, Le Corre D et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66: 3992-5.
• Douillard JY, Oliner KS, Siena S et al. Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013; 369: 1023-34.
• Moroni M, Veronese S, Benvenuti S et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 2005; 6: 279-86.
• Bouchahda M, Karaboue A, Saffroy R et al. Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis. Cancer Chemother Pharmacol 2010; 66 : 605-9.

タイトルに関連する用語 (7件)： 結腸直腸癌 ,  患者 ,  循環 ,  無細胞DNA ,  KRAS ,  突然変異検出 ,  有用性