文献

J-GLOBAL ID：201602235656133054   整理番号：16A1175925

パノビノスタットとポナチニブの組み合わせはイマチニブ耐性CML細胞を相乗的に克服する

Combination of panobinostat with ponatinib synergistically overcomes imatinib-resistant CML cells

著者 (11件)： Matsuda Yasufumi (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Yamauchi Takahiro (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Hosono Naoko (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Uzui Kanako (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Negoro Eiju (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Morinaga Koji (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Nishi Rie (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Yoshida Akira (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan) ,  Kimura Shinya (Division of Hematology, Respiratory Medicine and Oncology, Faculty of Medicine, Saga University, Saga, Japan) ,  Maekawa Taira (Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital, Kyoto, Japan) ,  Ueda Takanori (Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 107  号： 7  ページ： 1029-1038  発行年： 2016年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： CMLのイマチニブ(IM)耐性の主要なメカニズムはBCR-A...

シソーラス用語： *分子標的治療薬 ,...
準シソーラス用語： BCR/ABL ,...

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著者キーワード (5件)： Chronic myelogenous leukemia ,  combination therapy ,  imatinib-resistant ,  panobinostat ,  ponatinib

分類 (3件)： 腫ようの実験的治療  (GE02040Y) ,  血液の腫よう  (GK04000M) ,  その他の薬物の基礎研究  (GW23010K)

物質索引 (2件)： パノビノスタット ,  ポナチニブ

引用文献 (42件)：

• Kantarjian HM, Talpaz M. Definition of the accelerated phase of chronic myelogenous leukemia. J Clin Oncol 1988; 6: 180-2.
• Bartram CR, de Klein A, Hagemeijer A et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature 1983; 306: 277-80.
• Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nat Rev Cancer 2005; 5: 172-83.
• Groffen J, Stephenson JR, Heisterkamp N, de Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell 1984; 36:93-9.
• Lugo TG, Pendergast AM, Muller AJ, Witte ON. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990; 247: 1079-82.

タイトルに関連する用語 (4件)： パノビノスタット ,  ポナチニブ ,  組み合わせ ,  イマチニブ耐性